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Critical Reviews™ in Immunology
Facteur d'impact: 1.352 Facteur d'impact sur 5 ans: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v22.i4.40
22 pages

Autoimmunity to Glutamate Receptors in the Central Nervous System

Lorise C. Gahring
Salt Lake City VA-GRECC and University of Utah School of Medicine, Departments of Internal Medicine and Neurobiology and Anatomy, 2C110, 50 North Medical Drive, Salt Lake City, UT 84132
Scott W. Rogers
Salt Lake City VA-GRECC and University of Utah School of Medicine, Departments of Internal Medicine and Neurobiology and Anatomy, 2C110, 50 North Medical Drive, Salt Lake City, UT 84132

RÉSUMÉ

Autoimmunity to glutamate receptors (GluR) of the central nervous system offers an attractive model to begin the experimental dissection of the etiology of immune-related neurodegenerative diseases. Here we discuss the known mechanisms of generating autoimmunity to different members of the GluR neurotransmitter receptor family within the unique environment of the brain and how autoantibody-receptor interactions contribute to abnormal neurotransmission and eventually pathology.


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