Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
Role of the Glucocorticoid-Induced TNFR-Related Protein (GITR)-GITR Ligand Pathway in Innate and Adaptive Immunity
RÉSUMÉ
Glucocorticoid-induced TNF receptor-related protein (GITR) is expressed in regulatory T cells at high levels, but is also inducible in conventional effector T cells after activation. Initial studies using an agonistic anti- GITR mAb mislead this line of research with respect to the contribution of GITR stimulation on the function of regulatory T cells. In fact, GITR acts as a costimulatory receptor for both effector and regulatory T cells by enhancing effector and regulatory functions, respectively. Unlike other costimulatory ligands, GITR ligand (GITRL) expression on mature myeloid dendritic cells (DCs) is extremely limited and the GITR-GITRL pathway does not contribute markedly to direct interactions with T cells and antigen-presenting cells in the secondary lymphoid tissues. Rather, GITRL is constitutively expressed on parenchymal tissue cells and interacts with GITR expressed on tissue-infiltrating macrophages and DCs, or effector and regulatory T cells. Interactions with GITR and GITRL at local inflammatory sites induce site-specific production of cytokines and chemokines, resulting in control activation of tissue-infiltrating effector or regulatory cells and their migration. This review summarizes recent reports on the GITR-GITRL pathway, which controls both innate and adaptive immune responses.
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Whiteside Theresa L., Schuler Patrick, Schilling Bastian, Induced and natural regulatory T cells in human cancer, Expert Opinion on Biological Therapy, 12, 10, 2012. Crossref
-
Wortzman Michael E., Clouthier Derek L., McPherson Ann J., Lin Gloria H. Y., Watts Tania H., The contextual role of TNFR family members in CD8+T-cell control of viral infections, Immunological Reviews, 255, 1, 2013. Crossref
-
Xufré Cristina, Costa Manuela, Roura-Mir Carme, Codina-Busqueta Eva, Usero Lorena, Pizarro Eduarda, Obiols Gabriel, Jaraquemada Dolores, Martí Mercè, Low frequency of GITR+ T cells in ex vivo and in vitro expanded Treg cells from type 1 diabetic patients, International Immunology, 25, 10, 2013. Crossref
-
Vudattu Nalini K., Strle Klemen, Steere Allen C., Drouin Elise E., Dysregulation of CD4+CD25highT Cells in the Synovial Fluid of Patients With Antibiotic-Refractory Lyme Arthritis, Arthritis & Rheumatism, 65, 6, 2013. Crossref
-
Saito Keiichi, Mori Shiro, Date Fumiko, Ono Masao, Sjögren's syndrome-like autoimmune sialadenitis in MRL-Faslprmice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand, Autoimmunity, 46, 4, 2013. Crossref
-
Wang Shengjun, Shi Ye, Yang Min, Ma Jie, Tian Jie, Chen Jianguo, Mao Chaoming, Jiao Zhijun, Ko King-Hung, Baidoo Samuel Essien, Xu Huaxi, Hua Zichun, Lu Liwei, Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Protein Exacerbates Collagen-Induced Arthritis by Enhancing the Expansion of Th17 Cells, The American Journal of Pathology, 180, 3, 2012. Crossref
-
Ronchetti Simona, Nocentini Giuseppe, Petrillo Maria Grazia, Riccardi Carlo, CD8+T Cells: GITR Matters, The Scientific World Journal, 2012, 2012. Crossref
-
Byrne A. M., Goleva E., Chouiali F., Kaplan M. H., Hamid Q. A., Leung D. Y.M., Induction of GITRL expression in human keratinocytes by Th2 cytokines and TNF-α: implications for atopic dermatitis, Clinical & Experimental Allergy, 42, 4, 2012. Crossref
-
Gu Lei, Xu Lingxiao, Zhang Xiaojun, Tan Wenfeng, Wang Hong, Zhang Miaojia, Correlation of Circulating Glucocorticoid-Induced TNFR-Related Protein Ligand Levels with Disease Activity in Patients with Systemic Lupus Erythematosus, Clinical and Developmental Immunology, 2012, 2012. Crossref
-
Elgendy Ramy, Giantin Mery, Montesissa Clara, Dacasto Mauro, Transcriptomic analysis of skeletal muscle from beef cattle exposed to illicit schedules containing dexamethasone: identification of new candidate biomarkers and their validation using samples from a field monitoring trial, Food Additives & Contaminants: Part A, 32, 9, 2015. Crossref
-
Ronchetti Simona, Ricci Erika, Petrillo Maria Grazia, Cari Luigi, Migliorati Graziella, Nocentini Giuseppe, Riccardi Carlo, Glucocorticoid-Induced Tumour Necrosis Factor Receptor-Related Protein: A Key Marker of Functional Regulatory T Cells, Journal of Immunology Research, 2015, 2015. Crossref
-
Alegre Maria-Luisa, Chong Anita S., Costimulatory molecules, in Transplant Immunology, 2015. Crossref
-
应 亚萍, Recent Advance in GITR/GITRL Signaling Pathway and Bronchial Asthma, Asian Case Reports in Pediatrics, 01, 02, 2013. Crossref
-
Nocentini Giuseppe, Ronchetti Simona, Petrillo Maria Grazia, Riccardi Carlo, Pharmacological modulation of GITRL/GITR system: therapeutic perspectives, British Journal of Pharmacology, 165, 7, 2012. Crossref
-
Gerdes Norbert, Zirlik Andreas, Co-stimulatory molecules in and beyond co-stimulation – tipping the balance in atherosclerosis?, Thrombosis and Haemostasis, 106, 11, 2011. Crossref
-
Lisiecka Urszula, Kostro Krzysztof, Mechanisms of tumour escape from immune surveillance, Journal of Veterinary Research, 60, 4, 2016. Crossref
-
Liu Yingzhao, Tang Xinyi, Tian Jie, Zhu Chenlu, Peng Huiyong, Rui Ke, Wang Yungang, Mao Chaoming, Ma Jie, Lu Liwei, Xu Huaxi, Wang Shengjun, Th17/Treg Cells Imbalance and GITRL Profile in Patients with Hashimoto’s Thyroiditis, International Journal of Molecular Sciences, 15, 12, 2014. Crossref
-
Li Hui, Chen Hai-Ying, Liu Wen-Xuan, Jia Xian-Xian, Zhang Jing-Ge, Ma Chun-Ling, Zhang Xiao-Jing, Yu Feng, Cong Bin, Prostaglandin E2 restrains human Treg cell differentiation via E prostanoid receptor 2-protein kinase A signaling, Immunology Letters, 191, 2017. Crossref
-
Liao Gongxian, Driel Boaz, Magelky Erica, O'Keeffe Michael S., Waal Malefyt Rene, Engel Pablo, Herzog Roland W., Mizoguchi Emiko, Bhan Atul K., Terhorst Cox, Glucocorticoid‐induced TNF receptor family‐related protein ligand regulates the migration of monocytes to the inflamed intestine, The FASEB Journal, 28, 1, 2014. Crossref
-
Im Sun-A, Choi Hyun Sook, Choi Soon Ok, Kim Ki-Hyang, Lee Seungjeong, Hwang Bang Yeon, Lee Myung Koo, Lee Chong Kil, Restoration of Electric Footshock-Induced Immunosuppression in Mice by Gynostemma pentaphyllum Components, Molecules, 17, 7, 2012. Crossref
-
Whiteside Theresa L., Regulatory T Cells in Patients with Cancer, in The Tumor Immunoenvironment, 2013. Crossref
-
Placke Theresa, Salih Helmut R., Kopp Hans-Georg, GITR Ligand Provided by Thrombopoietic Cells Inhibits NK Cell Antitumor Activity, The Journal of Immunology, 189, 1, 2012. Crossref
-
Lacal Pedro Miguel, Petrillo Maria Grazia, Ruffini Federica, Muzi Alessia, Bianchini Rodolfo, Ronchetti Simona, Migliorati Graziella, Riccardi Carlo, Graziani Grazia, Nocentini Giuseppe, Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Ligand Triggering Upregulates Vascular Cell Adhesion Molecule-1 and Intercellular Adhesion Molecule-1 and Promotes Leukocyte Adhesion, Journal of Pharmacology and Experimental Therapeutics, 347, 1, 2013. Crossref
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Lin Gloria H. Y., Snell Laura M., Wortzman Michael E., Clouthier Derek L., Watts Tania H., GITR-Dependent Regulation of 4-1BB Expression: Implications for T Cell Memory and Anti–4-1BB–Induced Pathology, The Journal of Immunology, 190, 9, 2013. Crossref
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Tian Jie, Rui Ke, Hong Yue, Wang Xiaohui, Xiao Fan, Lin Xiang, Ma Jie, Guo Hongye, Xu Huaxi, Ma Kongyang, Xu Dong, Liu Dongzhou, Zhao Yan, Lu Liwei, Wang Shengjun, Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome, The Journal of Immunology, 202, 6, 2019. Crossref
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van der Werf Nienke, Redpath Stephen A., Phythian-Adams Alexander T., Azuma Miyuki, Allen Judith E., Maizels Rick M., MacDonald Andrew S., Taylor Matthew D., Th2 Responses to Helminth Parasites Can Be Therapeutically Enhanced by, but Are Not Dependent upon, GITR–GITR Ligand Costimulation In Vivo, The Journal of Immunology, 187, 3, 2011. Crossref
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Millán-Pérez Peña Lourdes, Martin Perez-Santos, Herrera-Camacho Irma, Bandala Cindy, Anaya-Ruiz Maricruz, Colon carcinoma treatment using bispecific anti-GITR/CTLA-4 antibodies: a patent evaluation of WO2018091739, Expert Opinion on Therapeutic Patents, 30, 5, 2020. Crossref
-
Gueuvoghlanian-Silva Bárbara Yasmin, Hernandes Camila, Correia Rodolfo Patussi, Podgaec Sergio, Deep Infiltrating Endometriosis and Activation and Memory Surface Markers and Cytokine Expression in Isolated Treg Cells, Reproductive Sciences, 27, 2, 2020. Crossref
-
Sakurai Tsuyoshi, Okuyama Yuko, Kobayashi Shuhei, Phung Hai The, Asao Atsuko, Kawabe Takeshi, Ndhlovu Lishomwa C., Riccardi Carlo, Kudo Hironori, Wada Motoshi, Nio Masaki, So Takanori, Ishii Naoto, GITR controls intestinal inflammation by suppressing IL‐15‐dependent NK cell activity, The FASEB Journal, 34, 11, 2020. Crossref
-
Nocentini Giuseppe, Cari Luigi, Riccardi Carlo, GITR : A Modulator of Regulatory and Effector T ‐Cell Activity, Crucial in Tumour Rejection and Autoimmune Diseases , in eLS, 2017. Crossref
-
Pattarabanjird Tanyaporn, Li Cynthia, McNamara Coleen, B Cells in Atherosclerosis, JACC: Basic to Translational Science, 6, 6, 2021. Crossref
-
Liao Gongxian, Detre Cynthia, Berger Scott B., Engel Pablo, de Waal Malefyt Rene, Herzog Roland W., Bhan Atul K., Terhorst Cox, Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Protein Regulates CD4+T Cell–Mediated Colitis in Mice, Gastroenterology, 142, 3, 2012. Crossref
-
Yang Lvlin, Chen Zhirong, Guo Haohui, Wang Zheng, Sun Kening, Yang Xiaochun, Zhao Xin, Ma Long, Wang Jian, Meng Zhiqiang, Jin Qunhua, Extensive cytokine analysis in synovial fluid of osteoarthritis patients, Cytokine, 143, 2021. Crossref
-
Ng Sze-Ling, Leno-Duran Ester, Samanta Dibyendu, Almo Steven C., Strominger Jack L., Genetically modified hematopoietic stem/progenitor cells that produce IL-10–secreting regulatory T cells, Proceedings of the National Academy of Sciences, 116, 7, 2019. Crossref