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Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.736 SNIP: 0.818 CiteScore™: 4.6

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v27.i2.20
pages 155-185

Biopolymers as Transdermal Drug Delivery Systems in Dermatology Therapy

K. H. Basavaraj
Department of Dermatology, JSS Medical College, JSS University, India
George Johnsy
Defense Food Research Laboratory, Siddhartha Nagar, Mysore, Karnataka, India
M.A. Navya
Department of Dermatology, Venereology and Leprosy, JSS Medical College, JSS University Mysore, Karnataka, India
R. Rashmi
Department of Dermatology, Venereology and Leprosy, JSS Medical College, JSS University Mysore, Karnataka, India
Siddaramaiah
Department of Polymer Science and Technology, Sri Jayachamarajendra College of Engineering, Mysore, Karnataka, India

RÉSUMÉ

The skin is considered a complex organ for drug delivery because of its structure. Drug delivery systems are designed for the controlled release of drugs through the skin into the systemic circulation, maintaining consistent efficacy and reducing the dose of the drugs and their related side effects. Transdermal drug delivery represents one of the most rapidly advancing areas of novel drug delivery. The excellent impervious nature of the skin is the greatest challenge that must be overcome for successful drug delivery. Today, polymers have been proven to be successful for long-term drug delivery applications as no single polymer can satisfy all of the requirements. Biopolymers in the field of dermal application are rare and the mechanisms that affect skin absorption are almost unknown. Biopolymers are widely used as drug delivery systems, but as such the use of biopolymers as drug delivery systems in dermatologic therapy is still in progress. Commonly used biopolymers include hydrocolloids, alginates, hydrogels, polyurethane, collagen, poly(lactic-co-glycolic acid), chitosan, proteins and peptides, pectin, siRNAs, and hyaluronic acid. These new and exciting methods for drug delivery are already increasing the number and quality of dermal and transdermal therapies. This article reviews current research on biopolymers and focuses on their potential as drug carriers, particularly in relation to the dermatologic aspects of their use.


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