Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.736 SNIP: 0.818 CiteScore™: 4.6

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

Volumes:
Volume 37, 2020 Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v23.i2.20
pages 111-135

Approaches to Oral Drug Delivery for Challenging Molecules

Gabriela Mustata
Emisphere Technologies Inc., Tarrytown, NY USA
Steven M. Dinh
Emisphere Technologies Inc., Tarrytown, NY USA

RÉSUMÉ

Advances in biotechnology, high throughput screening and computational chemistry have led to a considerable increase in the number of protein and peptide therapeutics and other macromolecular drugs. Working with macromolecules, however, poses a number of challenges that must be overcome to successfully develop these compounds into safe and effective therapeutics. Significant efforts in pharmaceutical and academic laboratories have been expended in finding ways to deliver macromolecular drug molecules by the oral route, which can significantly improve patient compliance, convenience, and efficacy. Nevertheless, for a drug molecule to be orally bioavailable, it has to overcome the natural physiological processes of breaking down molecules in the gastrointestinal tract, and to traverse a relatively impermeable epithelial layer of cells that line the gastrointestinal tract. This article provides a summary of the challenges that researchers need to surmount in the development of orally absorbable peptide and protein drugs, and gives an overview of the novel approaches currently in progress in the field of oral delivery.


Articles with similar content:

Targeted Delivery of Drugs to the Gastrointestinal Tract
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.18, 2001, issue 4
E. C. Lavelle
Osmotic Pumps in Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.21, 2004, issue 6
Sachin Arora, Sanjay Garg, Rajan K. Verma
Modification of Epithelial Tight Junction Integrity to Enhance Transmucosal Absorption
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.22, 2005, issue 4
Randall J. Mrsny
Nanostructured Lipid Carriers: A New Paradigm in Topical Delivery for Dermal and Transdermal Applications
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 4
Gajanand Sharma, Bhupinder Singh, Kaisar Raza, Om Parkash Katare, Kanika Thakur
Long-Acting Injectables: Current Perspectives and Future Promise
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.36, 2019, issue 2
Komal Chaudhary, Mayur M. Patel, Priti J. Mehta