Publication de 6 numéros par an
ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X
Indexed in
Pharmacodynamic Aspects of Modes of Drug Administration for Optimization of Drug Therapy
RÉSUMÉ
Because of various pharmacodynamic properties, such as the nonlinearity of the concentration-effect relationship, activation of feedback homeostatic mechanisms, induction of pharmacodynamic tolerance, etc., administration of die same dose of drug by different modes is expected to produce different outcomes. This review clarifies the theoretical and practical aspects of the impact of different modes of drag administration on the magnitude of response, and hence on therapy outcomes. It discusses how the interrelationship between the pharmacodynamic properties and die drug input function affects die magnitude of response. To demonstrate this special dimension of drug therapy, relevant pharmacodynamic data was obtained for drugs with different therapeutic applications, including antibiotics, analgesics, diuretics, anti-cancer, anti-ulcer, anti-inflammatory, anti-hypertensive, lipid-lowering anti-parkinsonian, and immunosuppressive drugs. These examples provide guidelines for implementing the role of the mode of drug administration (including rate, schedule, and route of drug treatment) during drug development or optimization of drug therapy.
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Stepensky David, The Øie–Tozer model of drug distribution and its suitability for drugs with different pharmacokinetic behavior, Expert Opinion on Drug Metabolism & Toxicology, 7, 10, 2011. Crossref
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Bomma Ramesh, Veerabrahma Kishan, Development of gastroretentive drug delivery system for cefuroxime axetil:In vitroandin vivoevaluation in human volunteers, Pharmaceutical Development and Technology, 18, 5, 2013. Crossref
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Gaur Praveen Kumar, Mishra Shikha, Kumar Avdhesh, Panda Bibhu Prasad, Development and optimization of gastroretentive mucoadhesive microspheres of gabapentin by Box–Behnken design, Artificial Cells, Nanomedicine, and Biotechnology, 42, 3, 2014. Crossref
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Klausner Eytan A., Lavy Eran, Stepensky David, Cserepes Eva, Barta Miklos, Friedman Michael, Hoffman Amnon, Furosemide Pharmacokinetics and Pharmacodynamics following Gastroretentive Dosage Form Administration to Healthy Volunteers, The Journal of Clinical Pharmacology, 43, 7, 2003. Crossref
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Rhee Yun-Seok, Park Seok, Lee Tae-Won, Park Chun-Woong, Nam Tae-Young, Oh Tack-Oon, Jeon Ji-Woong, Han Sang Beom, Lee Dong-Soo, Park Eun-Seok, In Vitro/in Vivo relationship of gabapentin from a sustained-release tablet formulation: A pharmacokinetic study in the beagle dog, Archives of Pharmacal Research, 31, 7, 2008. Crossref
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Barbanoj MJ, Ballester MR, Antonijoan RM, Puntes M, Gropper S, Santos B, Albet C, Guglietta A, A BIOAVAILABILITY/BIOEQUIVALENCE AND PHARMACOKINETIC STUDY OF TWO ORAL DOSES OF TORASEMIDE (5 AND 10 mg): PROLONGED-RELEASE VERSUS THE CONVENTIONAL FORMULATION, Clinical and Experimental Pharmacology and Physiology, 36, 5-6, 2009. Crossref
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Barbanoj M.J., Ballester M.R., Antonijoan R.M., Gich I., Pelagio P., Gropper S., Santos B., Guglietta A., Comparison of repeated-dose pharmacokinetics of prolonged-release and immediate-release torasemide formulations in healthy young volunteers, Fundamental & Clinical Pharmacology, 23, 1, 2009. Crossref
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Hoffman Amnon, Horwitz Ehud, Hess Shmuel, Cohen-Poradosu Ronit, Kleinberg Lilach, Edelberg Anna, Shapiro Mervyn, Implications on Emergence of Antimicrobial Resistance as a Critical Aspect in the Design of Oral Sustained Release Delivery Systems of Antimicrobials, Pharmaceutical Research, 25, 3, 2008. Crossref
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Klausner Eytan A, Lavy Eran, Friedman Michael, Hoffman Amnon, Expandable gastroretentive dosage forms, Journal of Controlled Release, 90, 2, 2003. Crossref
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Stepensky David, Friedman Michael, Srour Wassim, Raz Itamar, Hoffman Amnon, Preclinical evaluation of pharmacokinetic–pharmacodynamic rationale for oral CR metformin formulation, Journal of Controlled Release, 71, 1, 2001. Crossref
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Chavanpatil Mahesh, Jain Paras, Chaudhari Sachin, Shear Rajesh, Vavia Pradeep, Development of sustained release gastroretentive drug delivery system for ofloxacin: In vitro and in vivo evaluation, International Journal of Pharmaceutics, 304, 1-2, 2005. Crossref
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Mukker Jatinder Kaur, Singh Ravi Shankar Prasad, Derendorf Hartmut, Pharmacokinetic and pharmacodynamic implications in inhalable antimicrobial therapy, Advanced Drug Delivery Reviews, 85, 2015. Crossref
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Prinderre Pascal, Sauzet Christophe, Fuxen Claus, Advances in gastro retentive drug-delivery systems, Expert Opinion on Drug Delivery, 8, 9, 2011. Crossref
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Hu Liandong, Li Li, Yang Xun, Liu Wei, Yang Jianxue, Jia Yanhong, Shang Chuang, Xu Hongxin, Floating matrix dosage form for dextromethorphan hydrobromide based on gas forming technique: In vitro and in vivo evaluation in healthy volunteers, European Journal of Pharmaceutical Sciences, 42, 1-2, 2011. Crossref
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Stepensky David, Use of unbound volumes of drug distribution in pharmacokinetic calculations, European Journal of Pharmaceutical Sciences, 42, 1-2, 2011. Crossref
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Klausner Eytan A, Eyal Sara, Lavy Eran, Friedman Michael, Hoffman Amnon, Novel levodopa gastroretentive dosage form: in-vivo evaluation in dogs, Journal of Controlled Release, 88, 1, 2003. Crossref
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Hoffman Amnon, Stepensky David, Lavy Eran, Eyal Sara, Klausner Eytan, Friedman Michael, Pharmacokinetic and pharmacodynamic aspects of gastroretentive dosage forms, International Journal of Pharmaceutics, 277, 1-2, 2004. Crossref
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Goole J., Van Gansbeke B., Pilcer G., Deleuze Ph., Blocklet D., Goldman S., Pandolfo M., Vanderbist F., Amighi K., Pharmacoscintigraphic and pharmacokinetic evaluation on healthy human volunteers of sustained-release floating minitablets containing levodopa and carbidopa, International Journal of Pharmaceutics, 364, 1, 2008. Crossref
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Reich Reuven, Hoffman Amnon, Suresh R. Rama, Shai Ofra, Frant Julia, Maresca Alfonso, Supuran Claudiu T., Breuer Eli, Carbamoylphosphonates inhibit autotaxin and metastasis formationin vivo, Journal of Enzyme Inhibition and Medicinal Chemistry, 30, 5, 2015. Crossref
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Pillai Omathanu, Dhanikula Anand Babu, Panchagnula Ramesh, Drug delivery: an odyssey of 100 years, Current Opinion in Chemical Biology, 5, 4, 2001. Crossref
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Hoffman Amnon, Qadri Bashir A., Drug Delivery: Gastro-Retentive Systems, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2016. Crossref
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Satapathy Trilochan, Panda Prasana K., Goyal Amit K., Rath Goutam, Evaluation of Anti-GERD Activity of Gastro Retentive Drug Delivery System of Itopride Hydrochloride, Artificial Cells, Blood Substitutes, and Biotechnology, 38, 4, 2010. Crossref
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Bélair Jacques, Rimbu Andreea, Time Delays in Drug Administration: Effect, Transit, Tricks and Oscillations∗∗Financial support of the Natural Sciences and Enginering Research Council (NSERC, Canada) [Discovery Grant to JB], the Fonds de Recherche du Québec –Nature et Technologies (FRQNT, Québec) [Team Grant to JB and Doctoral Fellowship to AR] and Université de Montréal is acknowledged., IFAC-PapersOnLine, 48, 12, 2015. Crossref
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Ashraf Muhammad Umer, Hussain Muhammad Ajaz, Bashir Sajid, Haseeb Muhammad Tahir, Hussain Zakir, Quince seed hydrogel (glucuronoxylan): Evaluation of stimuli responsive sustained release oral drug delivery system and biomedical properties, Journal of Drug Delivery Science and Technology, 45, 2018. Crossref
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Wu Benjamin, Sy Sherwin K. B., Derendorf Hartmut, Principles of Applied Pharmacokinetic–Pharmacodynamic Modeling, in Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics, 2014. Crossref
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Stepensky David, Kleinberg Lilach, Hoffman Amnon, Bone as an Effect Compartment, Clinical Pharmacokinetics, 42, 10, 2003. Crossref
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Stepensky David, Friedman Michael, Raz Itamar, Hoffman Amnon, Pharmacokinetic-Pharmacodynamic Analysis of the Glucose-Lowering Effect of Metformin in Diabetic Rats Reveals First-Pass Pharmacodynamic Effect, Drug Metabolism and Disposition, 30, 8, 2002. Crossref
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Sy Sherwin K. B., Derendorf Hartmut, Pharmacometrics in Bacterial Infections, in Applied Pharmacometrics, 14, 2014. Crossref
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Sheikh Fatima Akbar, Hussain Muhammad Ajaz, Ashraf Muhammad Umer, Haseeb Muhammad Tahir, Farid-ul-Haq Muhammad, Linseed hydrogel based floating drug delivery system for fluoroquinolone antibiotics: Design, in vitro drug release and in vivo real-time floating detection, Saudi Pharmaceutical Journal, 28, 5, 2020. Crossref
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Yamani Lamya, Alamri Aisha, Alsultan Afnan, Alfifi Somaya, Ansari Mohammad Azam, Alnimr Amani, Inverse correlation between biofilm production efficiency and antimicrobial resistance in clinical isolates of Pseudomonas aeruginosa, Microbial Pathogenesis, 157, 2021. Crossref
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Patil Mayuri B., Maru Avish D., Bhadane Jayshree S., Formulation and Evaluation of Sustained Release Bilayer Matrix Tablet of Glimepiride and Metformin Hydrochloride, Asian Journal of Research in Pharmaceutical Sciences, 2021. Crossref
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Shang Wenting, Peng Li, Guo Pengyu, Hui Hui, Yang Xin, Tian Jie, Metal–Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration, ACS Biomaterials Science & Engineering, 6, 2, 2020. Crossref
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Patil Mayuri B., Salve Priyanka M., Sonawane Shital V., Maru Avish D., Bhadane Jayshree S., Surawase Rajendra K., Technologies in Bilayer Tablet Manufacturing: A Review, Research Journal of Pharmaceutical Dosage Forms and Technology, 2021. Crossref
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Jauregizar Nerea, Quindós Guillermo, Gil-Alonso Sandra, Suárez Elena, Sevillano Elena, Eraso Elena, Postantifungal Effect of Antifungal Drugs against Candida: What Do We Know and How Can We Apply This Knowledge in the Clinical Setting?, Journal of Fungi, 8, 7, 2022. Crossref