Publication de 6 numéros par an
ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X
Indexed in
Inflammatory Bowel Disease: Pathogenesis, Causative Factors, Issues, Drug Treatment Strategies, and Delivery Approaches
RÉSUMÉ
Inflammatory bowel disease (IBD) is an incessant, reverting, inflammatory disorder of the gastrointestinal tract encompassing two entities, namely, Crohn's disease (CD) and ulcerative colitis (UC). Numerous protocols have been explored to treat these dreadful diseases, including the use of different IBD drugs with different modes of action and routes of administration. Constant progression in the development of newer formulations, chemical modifications, stimuli-responsive systems, and novel approaches using colloidal and cellular carriers have led to effective treatments of gastric inflammation. Colloidal carriers including vesicular and particulate systems such as liposomes, transferosomes, solid lipid nanoparticles, microspheres; cellular carriers including erythrocytes, macrophages, and recombinant bacteria; and other systems such as osmotic pressure and plug control release have gained unique positions as drug carriers. Here, we investigate IBD in terms of its pathogenesis, role of genetic factors, currently available treatment options and their modes of action, pharmacokinetics, marketed products, side effects of individual IBD drugs, recent developments, modifications in the delivery of various drugs through novel colloidal drug carriers, and future prospects.
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Parihar Arun K. S., Srivastava Shikha, Patel Satish, Singh Manju R., Singh Deependra, Novel catalase loaded nanocores for the treatment of inflammatory bowel diseases, Artificial Cells, Nanomedicine, and Biotechnology, 45, 5, 2017. Crossref
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Shimizu Makoto, Multifunctions of dietary polyphenols in the regulation of intestinal inflammation, Journal of Food and Drug Analysis, 25, 1, 2017. Crossref
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Adesso Simona, Autore Giuseppina, Quaroni Andrea, Popolo Ada, Severino Lorella, Marzocco Stefania, The Food Contaminants Nivalenol and Deoxynivalenol Induce Inflammation in Intestinal Epithelial Cells by Regulating Reactive Oxygen Species Release, Nutrients, 9, 12, 2017. Crossref
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Corbo Claudia, Cromer Walter E., Molinaro Roberto, Toledano Furman Naama E., Hartman Kelly A., De Rosa Enrica, Boada Christian, Wang Xin, Zawieja David C., Agostini Marco, Salvatore Francesco, Abraham Bincy P., Tasciotti Ennio, Engineered biomimetic nanovesicles show intrinsic anti-inflammatory properties for the treatment of inflammatory bowel diseases, Nanoscale, 9, 38, 2017. Crossref
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Srivastava Shikha, Singh Deependra, Patel Satish, Singh Manju R., Role of enzymatic free radical scavengers in management of oxidative stress in autoimmune disorders, International Journal of Biological Macromolecules, 101, 2017. Crossref
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Srivastava Shikha, Singh Deependra, Singh Manju R., Folate-Conjugated Superoxide Dismutase Adsorbed Over Antioxidant Mimicking Nanomatrix Frameworks for Treatment of Rheumatoid Arthritis, Journal of Pharmaceutical Sciences, 107, 6, 2018. Crossref
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Chen Wei, Zhang Jing, Li Chen, Pan Quan, Wu Jingtong, Fan Lina, Chen Chunyan, Huang Xiaoqing, Teng Fei, Zhu Jinshui, Is dextran sulfate sodium a good inducer of acute experimental enteritis?, International Journal of Immunopathology and Pharmacology, 33, 2019. Crossref
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Zhang Sha, Cao Liang, Li Zhe, Qu Dingding, Metabolic reprogramming links chronic intestinal inflammation and the oncogenic transformation in colorectal tumorigenesis, Cancer Letters, 450, 2019. Crossref
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Singh Deependra, Parihar Arun KS, Patel Satish, Srivastava Shikha, Diwan Prakriti, Singh Manju R, Scleroderma: An insight into causes, pathogenesis and treatment strategies, Pathophysiology, 26, 2, 2019. Crossref
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Joseph Sharon Kunnath, Sabitha Mangalath, Nair Sreeja Chandrasekharan, Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery, Advanced Pharmaceutical Bulletin, 10, 1, 2019. Crossref
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Chen Ye, Shan Ting, Qu Huiheng, Chen Yigang, Wang Ning, Xia Jiazeng, Inhibition of miR-16 Ameliorates Inflammatory Bowel Disease by Modulating Bcl-2 in Mouse Models, Journal of Surgical Research, 253, 2020. Crossref
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Diling Chen, Xin Yang, Chaoqun Zheng, Jian Yang, Xiaocui Tang, Jun Chen, Ou Shuai, Yizhen Xie, Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota, Oncotarget, 8, 49, 2017. Crossref
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Hussain Tarique, Murtaza Ghulam, Yang Huansheng, Kalhoro Muhammad S., Kalhoro Dildar H., Exploiting Anti-Inflammation Effects of Flavonoids in Chronic Inflammatory Diseases, Current Pharmaceutical Design, 26, 22, 2020. Crossref
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Zhang Wunan, Michalowski Cecilia Bohns, Beloqui Ana, Oral Delivery of Biologics in Inflammatory Bowel Disease Treatment, Frontiers in Bioengineering and Biotechnology, 9, 2021. Crossref
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Santoru Maria Laura, Piras Cristina, Murgia Federica, Leoni Vera Piera, Spada Martina, Murgia Antonio, Liggi Sonia, Lai Maria Antonia, Usai Paolo, Caboni Pierluigi, Manzin Aldo, Atzori Luigi, Metabolic Alteration in Plasma and Biopsies From Patients With IBD, Inflammatory Bowel Diseases, 27, 8, 2021. Crossref
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Shakoor Hira, Feehan Jack, Apostolopoulos Vasso, Platat Carine, Al Dhaheri Ayesha Salem, Ali Habiba I., Ismail Leila Cheikh, Bosevski Marijan, Stojanovska Lily, Immunomodulatory Effects of Dietary Polyphenols, Nutrients, 13, 3, 2021. Crossref
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Chen Fengqian, Liu Qi, Xiong Yang, Xu Li, Current Strategies and Potential Prospects of Nanomedicine-Mediated Therapy in Inflammatory Bowel Disease, International Journal of Nanomedicine, Volume 16, 2021. Crossref
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Zhang Longlin, Yao Xiaofeng, Ma Mengmeng, Ding Yanan, Zhang Haihan, He Xi, Song Zehe, Protective Effect of l-Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-κB Signaling Pathway, Journal of Agricultural and Food Chemistry, 69, 47, 2021. Crossref
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Yasmin Farah, Najeeb Hala, Shaikh Shehryar, Hasanain Muhammad, Naeem Unaiza, Moeed Abdul, Koritala Thoyaja, Hasan Syedadeel, Surani Salim, Novel drug delivery systems for inflammatory bowel disease, World Journal of Gastroenterology, 28, 18, 2022. Crossref
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Wang Dongxu, Cai Min, Wang Taotao, Liu Tiantian, Huang Jinbao, Wang Yijun, Granato Daniel, Ameliorative effects of L-theanine on dextran sulfate sodium induced colitis in C57BL/6J mice are associated with the inhibition of inflammatory responses and attenuation of intestinal barrier disruption, Food Research International, 137, 2020. Crossref
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Rahman Mahfoozur, Kumar Vikas, Beg Sarwar, Sharma Gajanand, Katare Om Prakash, Anwar Firoz, Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art, Artificial Cells, Nanomedicine, and Biotechnology, 44, 7, 2016. Crossref
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Zanovello Mariana, Bolda Mariano Luísa Nathália, Cechinel-Zanchett Camile Cecconi, Boeing Thaise, Tazinaffo Gustavo Cembranelli, Mota da Silva Luisa, Silva Denise Brentan, Gasparotto Junior Arquimedes, de Souza Priscila, Tagetes erecta L. flowers, a medicinal plant traditionally used to promote diuresis, induced diuretic and natriuretic effects in normotensive and hypertensive rats, Journal of Ethnopharmacology, 279, 2021. Crossref
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Chi Jin Hua, Kim Young Ho, Sohn Dong Hwan, Seo Geom Seog, Lee Sung Hee, Ameliorative effect of Alnus japonica ethanol extract on colitis through the inhibition of inflammatory responses and attenuation of intestinal barrier disruption in vivo and in vitro, Biomedicine & Pharmacotherapy, 108, 2018. Crossref
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Zu Menghang, Ma Ya, Cannup Brandon, Xie Dengchao, Jung Yunjin, Zhang Jinming, Yang Chunhua, Gao Fei, Merlin Didier, Xiao Bo, Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases, Advanced Drug Delivery Reviews, 176, 2021. Crossref
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Luo Pan, Li Xuelin, Gao Yuan, Chen Zhengjun, Zhang Quanwei, Wang Zhimin, Tian Xiaozhu, Central administration of human opiorphin alleviates dextran sodium sulfate-induced colitis in mice through activation of the endogenous opioid system, Frontiers in Pharmacology, 13, 2022. Crossref