Publication de 6 numéros par an
ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X
Indexed in
Conundrum and Therapeutic Potential of Curcumin in Drug Delivery
RÉSUMÉ
Turmeric, the source of the polyphenolic active compound curcumin (diferuloylmethane), has been used extensively in traditional medicine since ancient times as a household remedy against various diseases, including hepatic disorders, cough, sinusitis, rheumatism, and biliary disorders. In the past few decades, a number of studies have been done on curcumin showing its potential role in treating inflammatory disorders, cardiovascular disease, cancer, AIDS, and neurological disorders. However, the main drawback associated with curcumin is its poor aqueous solubility and stability in gastrointestinal fluids, which leads to poor bioavailability. Multifarious novel drug-delivery approaches, including microemulsions, nanoemulsions, liposomes, solid lipid nanoparticles, microspheres, solid dispersion, polymeric nanoparticles, and self-microemulsifying drug-delivery systems have been used to enhance the bioavailability and tissue-targeting ability of curcumin. These attempts have revealed promising results for enhanced bioavailability and targeting to disease such as cancer, but more extensive research on tissue-targeting and stability-related issues is needed. Tissue targeting and enhanced bioavailability of curcumin using novel drug-delivery methods with minimum side effects will in the near future bring this promising natural product to the forefront of therapy for the treatment of human diseases such as cancer and cardiovascular ailments. We provide a detailed analysis of prominent research in the field of curcumin drug delivery with special emphasis on bioavailability-enhancement approaches and novel drug-delivery system approaches.
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Wei Xiao-Lan, Han Ying-Rui, Quan Li-Hui, Liu Chun-Yu, Liao Yong-Hong, Oily nanosuspension for long-acting intramuscular delivery of curcumin didecanoate prodrug: Preparation, characterization and in vivo evaluation, European Journal of Pharmaceutical Sciences, 49, 2, 2013. Crossref
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Kumar Anil, Ahuja Alka, Ali Javed, Baboota Sanjula, Curcumin-loaded lipid nanocarrier for improving bioavailability, stability and cytotoxicity against malignant glioma cells, Drug Delivery, 23, 1, 2016. Crossref
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Magro Massimiliano, Campos René, Baratella Davide, Lima Giuseppina, Holà Katerina, Divoky Clemens, Stollberger Rudolf, Malina Ondrej, Aparicio Claudia, Zoppellaro Giorgio, Zbořil Radek, Vianello Fabio, A Magnetically Drivable Nanovehicle for Curcumin with Antioxidant Capacity and MRI Relaxation Properties, Chemistry - A European Journal, 20, 37, 2014. Crossref
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Margulis Katherine, Magdassi Shlomo, Lee Han Seung, Macosko Christopher W., Formation of curcumin nanoparticles by flash nanoprecipitation from emulsions, Journal of Colloid and Interface Science, 434, 2014. Crossref
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PERRONE DONATELLA, ARDITO FATIMA, GIANNATEMPO GIOVANNI, DIOGUARDI MARIO, TROIANO GIUSEPPE, LO RUSSO LUCIO, DE LILLO ALFREDO, LAINO LUIGI, LO MUZIO LORENZO, Biological and therapeutic activities, and anticancer properties of curcumin, Experimental and Therapeutic Medicine, 10, 5, 2015. Crossref
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Vecchi Brumatti Liza, Marcuzzi Annalisa, Tricarico Paola, Zanin Valentina, Girardelli Martina, Bianco Anna, Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments, Molecules, 19, 12, 2014. Crossref
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Tubesha Zaki, Imam Mustapha, Mahmud Rozi, Ismail Maznah, Study on the Potential Toxicity of a Thymoquinone-Rich Fraction Nanoemulsion in Sprague Dawley Rats, Molecules, 18, 7, 2013. Crossref
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Javeri Indu, Chand Naresh, Curcumin, in Nutraceuticals, 2016. Crossref
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Maiti Panchanan, Hall Tia C., Paladugu Leela, Kolli Nivya, Learman Cameron, Rossignol Julien, Dunbar Gary L., A comparative study of dietary curcumin, nanocurcumin, and other classical amyloid-binding dyes for labeling and imaging of amyloid plaques in brain tissue of 5×-familial Alzheimer’s disease mice, Histochemistry and Cell Biology, 146, 5, 2016. Crossref
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Kadota Kazunori, Otsu Shigeyuki, Fujimori Miki, Sato Hideyuki, Tozuka Yuichi, Soluble hydrolysis-resistant composite formulation of curcumin containing α-glucosyl hesperidin and polyvinylpyrrolidone, Advanced Powder Technology, 27, 2, 2016. Crossref
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Yu Shaoxuan, Wang Yanru, Zhang Wentao, Zhang Yuhuan, Zhu Wenxin, Liu Yingnan, Zhang Daohong, Wang Jianlong, pH-Assisted surface functionalization of selenium nanoparticles with curcumin to achieve enhanced cancer chemopreventive activity, RSC Advances, 6, 76, 2016. Crossref
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Ishaka Aminu, Ismail Maznah, Imam Mustapha Umar, Mahmud Rozi, Sani Ismaila Muhammad, Zakaria Zuki Abu Bakar, Toxicity Evaluation, HET-CAM Irritation, and Anti-Irritant Potential of Rice Bran Wax Policosanol Nanoemulsion, Journal of Nano Research, 49, 2017. Crossref
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Dhule Santosh S., Penfornis Patrice, Frazier Trivia, Walker Ryan, Feldman Joshua, Tan Grace, He Jibao, Alb Alina, John Vijay, Pochampally Radhika, Chapter 10: Curcumin‒Loaded γ ‒Cyclodextrin Liposomal Nanoparticles as Delivery Vehicles for Osteosarcoma, in Nanomedicine in Cancer, 2017. Crossref
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Maiti Panchanan, Al-Gharaibeh Abeer, Kolli Nivya, Dunbar Gary L., Solid Lipid Curcumin Particles Induce More DNA Fragmentation and Cell Death in Cultured Human Glioblastoma Cells than Does Natural Curcumin, Oxidative Medicine and Cellular Longevity, 2017, 2017. Crossref
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Maiti Panchanan, Dunbar Gary L., Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42, International Journal of Alzheimer's Disease, 2017, 2017. Crossref
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Song Shengmei, Li Minglu, Gong Xiaojuan, Han Hui, Zhou Yehong, Wang Li, Shuang Shaomin, Dong Chuan, Controlled Release of Curcumin via Folic Acid Conjugated Magnetic Drug Delivery System, Chemical Research in Chinese Universities, 34, 2, 2018. Crossref
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Khomenko Olena, Budishevska Olga, Voronov Andriy, Kudina Olena, Tarnavchyk Ihor, Voronov Stanislav, Amphiphilic Oligomers Based On Diesters of Pyromellitic Acid for the Solubilization of Lipophilic Agents, International Journal of Theoretical and Applied Nanotechnology, 2013. Crossref
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Maiti Panchanan, Scott Jason, Sengupta Dipanwita, Al-Gharaibeh Abeer, Dunbar Gary, Curcumin and Solid Lipid Curcumin Particles Induce Autophagy, but Inhibit Mitophagy and the PI3K-Akt/mTOR Pathway in Cultured Glioblastoma Cells, International Journal of Molecular Sciences, 20, 2, 2019. Crossref
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Vaiserman Alexander, Koliada Alexander, Zayachkivska Alina, Lushchak Oleh, Nanodelivery of Natural Antioxidants: An Anti-aging Perspective, Frontiers in Bioengineering and Biotechnology, 7, 2020. Crossref
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Parsaei Mozhgan, Akhbari Kamran, Rutin-Based Phytomedicines for Cancer Benefit, in Nanomedicine for Bioactives, 2020. Crossref
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Olotu Fisayo, Agoni Clement, Soremekun Opeyemi, Soliman Mahmoud E. S., An Update on the Pharmacological Usage of Curcumin: Has it Failed in the Drug Discovery Pipeline?, Cell Biochemistry and Biophysics, 78, 3, 2020. Crossref
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Tan Kei-Xian, Ng Ling-Ling Evelyn, Loo Say Chye Joachim, Formulation Development of a Food-Graded Curcumin-Loaded Medium Chain Triglycerides-Encapsulated Kappa Carrageenan (CUR-MCT-KC) Gel Bead Based Oral Delivery Formulation, Materials, 14, 11, 2021. Crossref
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Mehrabi Masomeh, Karami Farahnaz, Siah Maryam, Esmaeili Sajjad, Khodarahmi Reza, Is curcumin an active suicidal antioxidant only in the aqueous environments?, Journal of the Iranian Chemical Society, 19, 8, 2022. Crossref
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Kalam Mohd Abul, Raish Mohammad, Ahmed Ajaz, Alkharfy Khalid M., Mohsin Kazi, Alshamsan Aws, Al-Jenoobi Fahad I., Al-Mohizea Abdullah M., Shakeel Faiyaz, Oral bioavailability enhancement and hepatoprotective effects of thymoquinone by self-nanoemulsifying drug delivery system, Materials Science and Engineering: C, 76, 2017. Crossref
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Celani Lívia Medeiros Soares, Egito Eryvaldo Sócrates Tabosa, Azevedo Ítalo Medeiros, Oliveira Cláudia Nunes, Dourado Douglas, Medeiros Aldo Cunha, Treatment of colitis by oral negatively charged nanostructured curcumin in rats, Acta Cirúrgica Brasileira, 37, 6, 2022. Crossref
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Arshad Noureen, Zia Khalid Mahmood, Hussain Muhammad Tahir, Zuber Mohammad, Arshad Muhammad Mubeen, Synthesis of novel curcumin-based aqueous polyurethane dispersions for medical textile diligences with potential of antibacterial activities, Polymer Bulletin, 79, 9, 2022. Crossref
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