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Critical Reviews™ in Therapeutic Drug Carrier Systems
Facteur d'impact: 2.9 Facteur d'impact sur 5 ans: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X

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Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.v28.i5.20
pages 447-488

Nanosuspensions in Drug Delivery: Recent Advances, Patent Scenarios, and Commercialization Aspects

Sandip S. Chavhan
Drug Delivery Laboratory, TIFAC CORE in NDDS, Pharmacy Department, Centre for PG Studies and Research, The M.S. University of Baroda, Vadodara, Gujarat, India
Kailash C. Petkar
Drug Delivery Laboratory, TIFAC CORE in NDDS, Pharmacy Department, Centre for PG Studies and Research, The M.S. University of Baroda, Vadodara, Gujarat, India
Krutika Sawant
The M.S.University of Baroda, Vadodara, Gujarat, India

RÉSUMÉ

The interest in the preparation and application of nanometer-sized materials is increasing due to their tremendous potential as a drug delivery system with wide range of applications. Recently, nanoscale systems have received much interest as a way to resolve solubility issues because of their cost-effectiveness and technical simplicity compared to liposomes and other colloidal drug carriers. Nanosuspensions have proven to be a better alternative over other approaches currently available for improving bioavailability of number of drugs with low solubility. Nanosuspensions have been extensively developed for a wide range of drugs and have been evaluated for in vitro and in vivo applications by various routes: parenteral, oral, pulmonary, topical. They have also been used for drug targeting. Different preparation methods for nanosuspensions and their application are being reported and patented. In fact, the number of products based on nanosuspension in the market and under clinical study is higher than that of other nanotechnology-based applications. This article reviews the research and recent advances in formulation, characterization, application of nanosuspensions as well as patents on nanosuspension methods.