Publication de 6 numéros par an
ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X
Indexed in
In Situ Forming Depot as Sustained-Release Drug Delivery Systems
RÉSUMÉ
In situ forming systems can serve as promising alternative to existing long acting injectables like disperse systems and microspheres, owing to their biocompatibility, stability, ease of administration and scale up. Microspheres based on long-acting parenteral systems pose challenges in scaling up and process changes with the drug and polymer selected. In situ gelling systems are having low viscosity which is very conducive during various manufacturing unit operations and passing the formulation through hypodermic needle with lower applied pressure. Different mechanisms such as physical or physiological stimuli and cross linking reactions are involved in the gelling of in situ forming systems at the site of injection. Drug release from in situ forming systems can be altered according to the need by using different polymers, lipids and fatty acids. In situ forming systems can be evaluated by sol-gel transition time, temperature and pH, rheology, gel strength, texture analysis, syringeability and injectability. The present paper is an overview of the various in situ gelling polymers and their application in the preparation of depot formulations. Numerous products based on in situ forming systems such as Eligard®, Atridox® are available in market.
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Ibrahim Tarek Metwally, El-Megrab Nagia Ahmed, El-Nahas Hanan Mohammed, An overview of PLGA in-situ forming implants based on solvent exchange technique: effect of formulation components and characterization, Pharmaceutical Development and Technology, 26, 7, 2021. Crossref
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Nagapudi Karthik, Zhu Aiden, Chang Debby P., Lomeo Joshua, Rajagopal Karthikan, Hannoush Rami N., Zhang Shawn, Microstructure, Quality, and Release Performance Characterization of Long-Acting Polymer Implant Formulations with X-Ray Microscopy and Quantitative AI Analytics, Journal of Pharmaceutical Sciences, 110, 10, 2021. Crossref
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Ammar Hussein O., Ibrahim Magdy, Mahmoud Azza A., Shamma Rehab N., El Hoffy Nada M., Polymer-Free Injectable In Situ Forming Nanovesicles as a New Platform for Controlled Parenteral Drug Delivery Systems, Journal of Pharmaceutical Innovation, 17, 2, 2022. Crossref
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Chandakavathe Baburao N., Kulkarni Ravindra G. , Dhadde Shivsharan B., Grafting of Natural Polymers and Gums for Drug Delivery Applications: A Perspective Review , Critical Reviews™ in Therapeutic Drug Carrier Systems, 39, 6, 2022. Crossref
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Singh Bhupinder, Sharma Teenu, Kaur Ranjot, Saini Sumant, Kaur Ripandeep, Beg Sarwar, QbD-Steered Systematic Development of Drug Delivery Nanoconstructs: Vital Precepts, Retrospect and Prospects, in Biomedical Translational Research, 2022. Crossref
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Chantadee Takron, Thammasut Warakon, Phaechamud Thawatchai, Fluid properties and phase transition of antimicrobial eudragit RS/clove oil in situ forming depot, Materials Today: Proceedings, 65, 2022. Crossref
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Lei Fang, Zhang Huimin, Luo Rui, Fei Qingsong, Bai Luyu, He Ning, Sustained ocular delivery of desmopressin acetate via thermoreversible in situ gel formulation: preparation and in vitro/in vivo evaluation, Journal of Pharmaceutical Investigation, 52, 5, 2022. Crossref
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Jin Zhiyu, Han Yu, Zhang Danshen, Li Zhongqiu, Jing Yongshuai, Hu Beibei, Sun Shiguo, Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients, Pharmaceutics, 14, 10, 2022. Crossref