Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Imprimer: 0893-9675
ISSN En ligne: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v5.i5.30
pages 473-538

Hodgkin's Disease: A Cytokine-Producing Tumor − A Review

Hans-Jurgen Gruss
Max-DelbrÜck Center for Molecular Medicine, Berlin-Buch, Germany lmmunex Research and Development Corporation, Seattle, WA
Friedhelm Herrmann
Max-DelbrÜck Center for Molecular Medicine, Berlin-Buch, Germany
Hans G. Drexler
German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany


Cytokines and hematopoietic growth factors are actively involved in regulation of proliferation, differentiation, and cellular functions of various cell lineages. Each cytokine exhibits pleiotropic biological functions on different target cells and subfamilies of cytokines often have redundant biological effects on the same target cell. Hodgkin's disease represents one of the most common human lymphoma entities, the molecular pathogenesis of which is not well understood. Hodgkin's disease is characterized by the presence of typical, presumed malignant Hodgkin and Reed-Sternberg cells in a hyperplastic background of normal reactive lymphocytes, plasma cells, histiocytes, neutrophils, eosinophils, and stromal cells. The histopathological presentation and characteristic clinical features of Hodgkin's disease correlate with an unbalanced production of multiple cytokines. Hodgkin and Reed-Sternberg cells express mRNA and proteins of various cytokines, growth factors, and cytokine receptors, implying a predominant role for cytokines in the pathophysiology of Hodgkin's disease as a tumor of cytokine-producing cells.

Articles with similar content:

The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease
Critical Reviews™ in Immunology, Vol.36, 2016, issue 4
Veronica M. Ringel-Scaia, Irving C. Allen, Dylan K. McDaniel
The Role of Dectin-1 in Antifungal Immunity
Critical Reviews™ in Immunology, Vol.24, 2004, issue 3
Siamon Gordon, Jurgen Herre, Janet A. Willment, Gordon D. Brown
Molecular and Functional Interactions Among Monocytes/Macrophages and Smooth Muscle Cells and Their Relevance for Atherosclerosis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.24, 2014, issue 4
Ileana Manduteanu, Ana Maria Gan, Elena Butoi
Reflections on Lineage Potential of Skeletal Muscle Satellite Cells: Do They Sometimes Go MAD?
Critical Reviews™ in Eukaryotic Gene Expression, Vol.17, 2007, issue 1
Zipora Yablonka-Reuveni, Gabi Shefer
Transcription Factors and Th17 Cell Development in Experimental Autoimmune Encephalomyelitis
Critical Reviews™ in Immunology, Vol.33, 2013, issue 2
Guobing Chen, M. Frances Shannon