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Critical Reviews™ in Oncogenesis

Publication de 4  numéros par an

ISSN Imprimer: 0893-9675

ISSN En ligne: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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NK Cell Phenotypic and Functional Heterogeneities and Molecular Mechanisms of Cytotoxicity

Volume 19, Numéro 1-2, 2014, pp. 21-45
DOI: 10.1615/CritRevOncog.2014010804
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RÉSUMÉ

Natural killer (NK) cells were discovered four decades ago, independently, by the Kiessling and Herberman groups. Since then, significant advances have accrued regarding the functional and molecular properties of NK cells as well as their clinical relevance. The important feature of NK cells is their inability to kill normal cells, while they are highly cytotoxic for infected or transformed cells. This discrimination has been largely resolved by the discovery of both activating and inhibitory receptors on NK cells and corresponding ligands on target cells. This review focuses briefly on several issues related to NK cells: (1) the phenotypic properties of NK cells, (2) the heterogeneity of NK cell activities, (3) the determination of three major NK subsets (Free, Binder, and Killer), (4) the maturation and activation of NK subsets, (5) the response of NK cells to various cytokines, (6) the target-induced inactivation and cell death of NK cells, (7) the multiple mechanisms of cell-mediated cytotoxicity, (8) the characterization of NK cytotoxic factors (NKCF), and (9) the role of membrane fluidity in cytotoxicity. These subjects are described chronologically beginning shortly after the discovery of NK cells as a result of Ron Herberman's leadership, and I am gratefully indebted to him.

CITÉ PAR
  1. Verma Chandan, Kaewkangsadan Viriya, Eremin Jennifer M, Cowley Gerard P, Ilyas Mohammad, El-Sheemy Mohamed A, Eremin Oleg, Natural killer (NK) cell profiles in blood and tumour in women with large and locally advanced breast cancer (LLABC) and their contribution to a pathological complete response (PCR) in the tumour following neoadjuvant chemotherapy (NAC): differential restoration of blood profiles by NAC and surgery, Journal of Translational Medicine, 13, 1, 2015. Crossref

  2. Gallardo-Vera Francisco, Diaz Daniel, Tapia-Rodriguez Miguel, Fortoul van der Goes Teresa, Masso Felipe, Rendon-Huerta Erika, Montaño Luis F., Vanadium pentoxide prevents NK-92MI cell proliferation and IFNγsecretion through sustained JAK3 phosphorylation, Journal of Immunotoxicology, 13, 1, 2016. Crossref

  3. Zheng Kexin, Fan Yudan, Ji Ruiqin, Ma Shiliang, Distinctive effects of pilose antler on mouse peripheral blood immune cell populations, Food and Agricultural Immunology, 28, 6, 2017. Crossref

  4. Fenerty Kathleen E., Padget Michelle, Wolfson Benjamin, Gameiro Sofia R., Su Zhen, Lee John H., Rabizadeh Shahrooz, Soon-Shiong Patrick, Hodge James W., Immunotherapy utilizing the combination of natural killer– and antibody dependent cellular cytotoxicity (ADCC)–mediating agents with poly (ADP-ribose) polymerase (PARP) inhibition, Journal for ImmunoTherapy of Cancer, 6, 1, 2018. Crossref

  5. Bonavida Benjamin, Sensitization of Immune-Resistant Tumor Cells to CTL-Mediated Apoptosis via Interference at the Dysregulated NF-κB/Snail/YY1/PI3K/RKIP/PTEN Resistant Loop, in Resistance of Cancer Cells to CTL-Mediated Immunotherapy, 7, 2015. Crossref

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