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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Imprimer: 0893-9675
ISSN En ligne: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2018026148
pages 13-37

Radiation-Induced Cell Death: Signaling and Pharmacological Modulation

Alex Philchenkov
Department of Oncohematology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

RÉSUMÉ

Currently, more than half of newly diagnosed cancer patients receive radiation treatment. However, the radioresistance of tumor cells as well as the early and late side effects limit the beneficial outcome of radiotherapy. Accordingly, the innovative approaches to maximize tumor killing and/or minimize radiation toxicity remain a major focus of interest. In the past decade, several pieces of evidence have shown the importance of different modes of regulated cell death (RCD) in the radioresponse of malignant and normal tissues. Furthermore, the biological modulation of radiation-induced RCDs has come to attention as a novel therapeutic means. Here, we review the major signaling pathways that orchestrate all types of RCD initiated by exposure to ionizing radiation. The latest advances in the development of small-molecule RCD modulators (both natural and synthetic) that are intended for widening the therapeutic window of radiotherapy are also discussed.


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