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Critical Reviews™ in Oncogenesis

Publication de 4  numéros par an

ISSN Imprimer: 0893-9675

ISSN En ligne: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Iron in Hodgkin's Lymphoma

Volume 18, Numéro 5, 2013, pp. 463-469
DOI: 10.1615/CritRevOncog.2013007765
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RÉSUMÉ

Anemia is a frequent finding of Hodgkin's lymphoma (HL) diagnosis. It is usually mild, with hemoglobin levels between 10 and 12 g/dl; it is rarely (<10% of cases) a result of bone marrow infiltration; and it displays the characteristics of the anemia of chronic disease due to abnormalities in iron metabolism. The inflammatory cytokine IL-6 is frequently up-regulated in Hodgkin's lymphoma, and IL-6 levels are strongly associated with hepcidin, the main regulator of iron metabolism. Elevated hepcidin levels result in iron restriction and signs of anemia of chronic disease. In addition, the abundant microenvironment surrounding the neoplastic Hodgkin's and Reed-Sternberg cells may contribute to alterations in iron metabolism. Tumor-infiltrating macrophages can sequester iron using scavenger receptors. Iron-restricted anemia at HL diagnosis can be aggravated by intensive chemotherapy, and iron overload may become clinically relevant in heavily treated patients with relapsed or refractory disease undergoing high-dose chemotherapy and stem cell transplantation.

CITÉ PAR
  1. Fernandez-Alvarez Ruben, Gonzalez-Rodriguez Ana P., Gonzalez M. Esther, Rubio-Castro Arturo, Dominguez-Iglesias Francisco, Solano Jackeline, Alonso-Nogues Eva, Fernandez-Alvarez Carmen, Zanabili Yahya, Alonso Jose Manuel, Payer Angel Ramirez, Vicente Jose Maria, Medina Jesus, Sancho Juan M., Serum ferritin as prognostic marker in classical Hodgkin lymphoma treated with ABVD-based therapy, Leukemia & Lymphoma, 56, 11, 2015. Crossref

  2. deAndrés-Galiana E. J., Fernández-Martínez J. L., Luaces O., del Coz J. J., Fernández R., Solano J., Nogués E. A., Zanabilli Y., Alonso J. M., Payer A. R., Vicente J. M., Medina J., Taboada F., Vargas M., Alarcón C., Morán M., González-Ordóñez A., Palicio M. A., Ortiz S., Chamorro C., Gonzalez S., González-Rodríguez A. P., On the prediction of Hodgkin lymphoma treatment response, Clinical and Translational Oncology, 17, 8, 2015. Crossref

  3. Reichert Cadiele Oliana, da Cunha Joel, Levy Débora, Maselli Luciana Morganti Ferreira, Bydlowski Sérgio Paulo, Spada Celso, Hepcidin: Homeostasis and Diseases Related to Iron Metabolism, Acta Haematologica, 137, 4, 2017. Crossref

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