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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Imprimer: 0893-9675
ISSN En ligne: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2014011563
pages 223-245

Nanoparticle Drug Formulations for Cancer Diagnosis and Treatment

Wilson Poon
Department of Biomedical Engineering, McGill University, Montreal, Canada
Xuan Zhang
Department of Biomedical Engineering, McGill University, Montreal, Canada
Jay Nadeau
Department of Biomedical Engineering, McGill University, Montreal, Canada

RÉSUMÉ

Over the past ten years, more than a billion dollars in U.S. government funding has been awarded to the development of nanomaterials for clinical diagnosis and therapy. In this article we will focus on one subset of nanotechnology: nanoparticle formulations of drugs intended to diagnose or treat cancer. Several nanoparticle drug preparations are now in widespread clinical use, and dozens are in the pipeline. In some cases the nanoparticles are simply passive drug carriers or contrast agents; in others, the nanoparticles have active therapeutic properties. Cancer, particularly solid tumors, is one of nanotechnology's key targets. The specific challenges involved in cancer treatment are those addressed by multifunctional materials, in particular, inaccessibility, widespread metastasis, low oxygen concentrations, and resistance to drugs and radiation. Nonetheless, major barriers still remain to effective nanoparticle design and approval.


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