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Critical Reviews™ in Oncogenesis

Publication de 4  numéros par an

ISSN Imprimer: 0893-9675

ISSN En ligne: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Cancer and Cancer Stem Cells: New Molecular Perspectives

Volume 24, Numéro 1, 2019, pp. 99-104
DOI: 10.1615/CritRevOncog.2019029628
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RÉSUMÉ

Cancer, which causes the deaths of millions of people, is an important public health problem worldwide. Despite significant advances in the diagnosis and treatment of cancer, survival rates are still insufficient in progressive cancers. Today, one of the most important reasons for not being able to reach the desired level in the fight against progressive cancer types is cancer stem cells (CSCs). The ineffectiveness of conventional therapies on CSCs has made it necessary to investigate the molecular mechanisms and signaling pathways used in the survival, drug resistance, and metastasis of CSCs. In this context, studies investigating the biology of CSCs suggest that lipid metabolism and extracellular vesicles are critical for understanding the stemness and metastasis of these cells. These studies have demonstrated that a number of molecules play a vital role in resistant to apoptosis in CSCs, including the cellular FLICE-inhibitor protein (c-FLIP), which inhibits TRAIL-induced extrinsic apoptosis. Another important output of these studies is the demonstration of the relationship of the cancer microenvironment in terms of epithelial–mesenchymal transition, which CSCs frequently use in the metastasis process. In addition, studies investigating the differences in glycosylation observed in CSCs and investigating cancer vaccines are promisng. These findings will strengthen our aresnal in the fight against cancer. In this article, we summarize current molecular studies on CSCs, an important target in novel cancer therapies.

CITÉ PAR
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  3. Xu Ran, Liu Tianhua, Zuo Ling, Guo Dongqing, Ye Guancheng, Jiang Jingjing, Yu Xue, Zhang Shujing, Hou Chunying, The high expression of miR-31 in lung adenocarcinoma inhibits the malignancy of lung adenocarcinoma tumor stem cells, Biochemistry and Biophysics Reports, 28, 2021. Crossref

  4. O’Rawe Michael, Kilmister Ethan J., Mantamadiotis Theo, Kaye Andrew H., Tan Swee T., Wickremesekera Agadha C., The Renin–Angiotensin System in the Tumor Microenvironment of Glioblastoma, Cancers, 13, 16, 2021. Crossref

  5. Turan Hasan, Vitale Salvatore Giovanni, Kahramanoglu Ilker, Della Corte Luigi, Giampaolino Pierluigi, Azemi Asli, Durmus Sinem, Sal Veysel, Tokgozoglu Nedim, Bese Tugan, Arvas Macit, Demirkiran Fuat, Gelisgen Remise, Ilvan Sennur, Uzun Hafize, Diagnostic and prognostic role of TFF3, Romo-1, NF-кB and SFRP4 as biomarkers for endometrial and ovarian cancers: a prospective observational translational study, Archives of Gynecology and Obstetrics, 2022. Crossref

  6. Zou Weiyan, Zhang Yi, Bai Guangfu, Zhuang Jialu, Wei Lin, Wang Zishu, Sun Meiqun, Wang Junbin, siRNA‐induced CD44 knockdown suppresses the proliferation and invasion of colorectal cancer stem cells through inhibiting epithelial–mesenchymal transition, Journal of Cellular and Molecular Medicine, 26, 7, 2022. Crossref

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