Abonnement à la biblothèque: Guest
Critical Reviews™ in Oncogenesis

Publication de 4  numéros par an

ISSN Imprimer: 0893-9675

ISSN En ligne: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Cell Fusion In Tumor Development: Accelerated Genetic Evolution

Volume 18, Numéro 1-2, 2013, pp. 19-42
DOI: 10.1615/CritRevOncog.v18.i1-2.30
Get accessGet access

RÉSUMÉ

The majority of human tumor cells have highly aberrant karyotypes, typically ascribed to errors during tumor cell division, potentially linked to a failure of DNA repair, or telomeric insufficiency. Here we discuss another option, that of cell fusion which can lead to the re-assortment of chromosomes during post-fusion mitosis. The observation of hyperdiploid cells has a long history in cancer genetics, but the concept of cell fusion has been difficult to test in practice. Here, we examine the role of cell fusion during normal development, and relate that to potential cellular fusion partners for primary tumor cells. In particular, we describe the potential for stromal partner fusion during metastatic mobilization. The evidence for genetic and cytoplasmic diversity in heterotypic fusion partners is described, together with the new tools available to help the evaluation of this process as a tumor driver.

CITÉ PAR
  1. Zhou Xiaofeng, Merchak Kevin, Lee Woojin, Grande Joseph P., Cascalho Marilia, Platt Jeffrey L., Cell Fusion Connects Oncogenesis with Tumor Evolution, The American Journal of Pathology, 185, 7, 2015. Crossref

  2. Shinn-Thomas Jessica H., del Campo Jacob J., Wang Jianjun, Mohler William A., Prigent Claude, The EFF-1A Cytoplasmic Domain Influences Hypodermal Cell Fusions in C. elegans But Is Not Dependent on 14-3-3 Proteins, PLOS ONE, 11, 1, 2016. Crossref

  3. Kurgyis Zsuzsanna, Kemény Lajos, Buknicz Tünde, Groma Gergely, Oláh Judit, Jakab Ádám, Polyánka Hilda, Zänker Kurt, Dittmar Thomas, Kemény Lajos, Németh István, Melanoma-Derived BRAFV600E Mutation in Peritumoral Stromal Cells: Implications for in Vivo Cell Fusion, International Journal of Molecular Sciences, 17, 6, 2016. Crossref

  4. SHEN YUNTIAN, ZHANG QUANBIN, ZHANG JINSHI, LU ZHAOHUI, WANG AIDONG, FEI XIFENG, DAI XINGLIANG, WU JINDING, WANG ZHIMIN, ZHAO YAODONG, TIAN YE, DONG JUN, LAN QING, HUANG QIANG, Advantages of a dual-color fluorescence-tracing glioma orthotopic implantation model: Detecting tumor location, angiogenesis, cellular fusion and the tumor microenvironment, Experimental and Therapeutic Medicine, 10, 6, 2015. Crossref

  5. Kemény Lajos, Kurgyis Zsuzsanna, Buknicz Tünde, Groma Gergely, Jakab Ádám, Zänker Kurt, Dittmar Thomas, Kemény Lajos, Németh István, Melanoma Cells Can Adopt the Phenotype of Stromal Fibroblasts and Macrophages by Spontaneous Cell Fusion in Vitro, International Journal of Molecular Sciences, 17, 6, 2016. Crossref

  6. Goldenberg David M., Rooney Robert J., Loo Meiyu, Liu Donglin, Chang Chien-Hsing, Dittmar Thomas, In-Vivo Fusion of Human Cancer and Hamster Stromal Cells Permanently Transduces and Transcribes Human DNA, PLoS ONE, 9, 9, 2014. Crossref

  7. Clawson Gary, The Fate of Fusions, Cells, 8, 1, 2018. Crossref

  8. Parris George E., Cell-Cell Fusion, Chemotaxis and Metastasis, in Intercellular Communication in Cancer, 2015. Crossref

  9. Manjunath Yariswamy, Porciani David, Mitchem Jonathan B., Suvilesh Kanve N., Avella Diego M., Kimchi Eric T., Staveley-O’Carroll Kevin F., Burke Donald H., Li Guangfu, Kaifi Jussuf T., Tumor-Cell–Macrophage Fusion Cells as Liquid Biomarkers and Tumor Enhancers in Cancer, International Journal of Molecular Sciences, 21, 5, 2020. Crossref

  10. Osychenko Alina, Zalessky Alexandr, Astafiev Artyom, Shakhov Aleksander, Kostrov Andrey, Krivokharchenko Alexandr, Nadtochenko Viktor, Femtosecond laser-induced blastomere fusion results in embryo tetraploidy by common metaphase plate formation, Experimental Cell Research, 389, 1, 2020. Crossref

  11. Li Zugui, Zheng Minying, Zhang Hao, Yang Xiaohui, Fan Linlin, Fu Fangmei, Fu Junjie, Niu Rui, Yan Man, Zhang Shiwu, Arsenic Trioxide Promotes Tumor Progression by Inducing the Formation of PGCCs and Embryonic Hemoglobin in Colon Cancer Cells, Frontiers in Oncology, 11, 2021. Crossref

  12. Uygur Berna, Leikina Evgenia, Melikov Kamran, Villasmil Rafael, Verma Santosh K., Vary Calvin P.H., Chernomordik Leonid V., Interactions with Muscle Cells Boost Fusion, Stemness, and Drug Resistance of Prostate Cancer Cells, Molecular Cancer Research, 17, 3, 2019. Crossref

  13. Freeman Brian T., Ogle Brenda M., Viral-mediated fusion of mesenchymal stem cells with cells of the infarcted heart hinders healing via decreased vascularization and immune modulation, Scientific Reports, 6, 1, 2016. Crossref

Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain