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Critical Reviews™ in Oncogenesis

Publication de 4  numéros par an

ISSN Imprimer: 0893-9675

ISSN En ligne: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Newer Trends in Pancreatic Cancer Treatment: Genetic Alterations and the Role of Immune Therapeutic and Targeted Therapies

Volume 24, Numéro 2, 2019, pp. 157-177
DOI: 10.1615/CritRevOncog.2019031642
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RÉSUMÉ

Pancreatic cancer prognosis has remained poor and no significant improvement has been achieved over the past two decades. A number of genetic alterations are found in pancreatic cancer with a complex genome and proteome that needs further research investigation and discovery. There is an urgent need for innovative research findings that would increase the 5-year survival rate in patients with pancreatic ductal carcinoma, which in fact has seen only small increments over the past two decades. Targeting the tumor and modifying the stroma could help improve therapy responses. Genomic medicine is useful in a fraction of patients currently; however, the newer proteomic approaches are potentially more likely to help the majority of patients in the future. Future treatments of pancreatic cancer will likely be based on the development of novel therapies per genomic and proteomic identifications of cellular/immunological processes and molecular pathways as therapeutic targets. Herein, we systematically review the newer trends in pancreatic cancer treatment with emphasis on the genetic alterations and role of immune therapeutics and targeted therapies.

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CITÉ PAR
  1. Wang Yali, Zheng Kun, Xiong Hua, Huang Yongbiao, Chen Xiuqiong, Zhou Yilu, Qin Wan, Su Jinfang, Chen Rui, Qiu Hong, Yuan Xianglin, Wang Yihua, Zou Yanmei, PARP Inhibitor Upregulates PD-L1 Expression and Provides a New Combination Therapy in Pancreatic Cancer, Frontiers in Immunology, 12, 2021. Crossref

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