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Critical Reviews™ in Oncogenesis

Publication de 4  numéros par an

ISSN Imprimer: 0893-9675

ISSN En ligne: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Anoikis and EMT: Lethal "Liaisons" during Cancer Progression

Volume 21, Numéro 3-4, 2016, pp. 155-168
DOI: 10.1615/CritRevOncog.2016016955
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RÉSUMÉ

Anoikis is a unique mode of apoptotic cell death that occurs consequentially to insufficient cell-matrix interactions. Resistance to anoikis is a critical contributor to tumor invasion and metastasis. The phenomenon is regulated by integrins, which upon engagement with components of the extracellular matrix (ECM) form adhesion complexes and the actin cytoskeleton drives the formation of cell protrusions used to adhere to ECM, directing cell migration. The epithelial-mesenchymal transition (EMT) confers stem cell properties and leads to acquisition of a migratory and invasive phenotype by causing adherens junction breakdown and circumventing anoikis in the tumor microenvironment. The investigation of drug discovery platforms for apoptosis-driven therapeutics identified several novel agents with antitumor action via reversing resistance to anoikis, inhibiting survival pathways and impacting the EMT landscape in human cancer. In this review, we discuss current evidence on the contribution of the anoikis phenomenon functionally linked to EMT to cancer metastasis and the therapeutic value of antitumor drugs that selectively reverse anoikis resistance and/or EMT to impair tumor progression toward the development/optimization of apoptosis-driven therapeutic targeting of metastatic disease.

CITÉ PAR
  1. Guerra Flora, Guaragnella Nicoletta, Arbini Arnaldo A., Bucci Cecilia, Giannattasio Sergio, Moro Loredana, Mitochondrial Dysfunction: A Novel Potential Driver of Epithelial-to-Mesenchymal Transition in Cancer, Frontiers in Oncology, 7, 2017. Crossref

  2. Nieberler Markus, Reuning Ute, Reichart Florian, Notni Johannes, Wester Hans-Jürgen, Schwaiger Markus, Weinmüller Michael, Räder Andreas, Steiger Katja, Kessler Horst, Exploring the Role of RGD-Recognizing Integrins in Cancer, Cancers, 9, 12, 2017. Crossref

  3. Kakavandi Ehsan, Shahbahrami Ramin, Goudarzi Hossein, Eslami Gita, Faghihloo Ebrahim, Anoikis resistance and oncoviruses, Journal of Cellular Biochemistry, 119, 3, 2018. Crossref

  4. Stark Timothy W., Hensley Patrick J., Spear Amanda, Pu Hong, Strup Stephen S., Kyprianou Natasha, Predictive value of epithelial-mesenchymal-transition (EMT) signature and PARP-1 in prostate cancer radioresistance, The Prostate, 77, 16, 2017. Crossref

  5. Francart Marie-Emilie, Lambert Justine, Vanwynsberghe Aline M., Thompson Erik W., Bourcy Morgane, Polette Myriam, Gilles Christine, Epithelial-mesenchymal plasticity and circulating tumor cells: Travel companions to metastases, Developmental Dynamics, 247, 3, 2018. Crossref

  6. Kim Do, Xing Tiaosi, Yang Zhibin, Dudek Ronald, Lu Qun, Chen Yan-Hua, Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview, Journal of Clinical Medicine, 7, 1, 2017. Crossref

  7. Giopanou Ioanna, Arendt Kristina A.M., Stathopoulos Georgios T., Lung carcinogenesis and fibrosis taken together, Current Opinion in Pulmonary Medicine, 23, 4, 2017. Crossref

  8. Li Ming, Qian Zhimin, Ma Xiaoling, Lin Xiaolong, You Yanan, Li Yiying, Chen Tong, Jiang Hua, MiR-628-5p decreases the tumorigenicity of epithelial ovarian cancer cells by targeting at FGFR2, Biochemical and Biophysical Research Communications, 495, 2, 2018. Crossref

  9. Saxena Meera, Kalathur Ravi Kiran Reddy, Neutzner Melanie, Christofori Gerhard, PyMT-1099, a versatile murine cell model for EMT in breast cancer, Scientific Reports, 8, 1, 2018. Crossref

  10. Niu Leilei, Ni Hua, Hou Yingzi, Du Quan, Li Hua, miR-509-3p enhances platinum drug sensitivity in ovarian cancer, Gene, 686, 2019. Crossref

  11. García-Jiménez Custodia, Goding Colin R., Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming, Cell Metabolism, 29, 2, 2019. Crossref

  12. Terasaki Masaru, Iida Tatsuya, Kikuchi Fubuki, Tamura Kanae, Endo Tetsuya, Kuramitsu Yasuhiro, Tanaka Takuji, Maeda Hayato, Miyashita Kazuo, Mutoh Michihiro, Fucoxanthin potentiates anoikis in colon mucosa and prevents carcinogenesis in AOM/DSS model mice, The Journal of Nutritional Biochemistry, 64, 2019. Crossref

  13. Shimura Tatsuo, Kofunato Yasuhide, Okada Ryo, Yashima Rei, Koyama Yoshihisa, Araki Kenichiro, Kuwano Hiroyuki, Takenoshita Seiichi, Intranuclear accumulation of galectin-3 is an independent prognostic factor for patients with distal cholangiocarcinoma, Oncology Letters, 14, 1, 2017. Crossref

  14. Redfern Andrew D., Spalding Lisa J., Thompson Erik W., The Kraken Wakes: induced EMT as a driver of tumour aggression and poor outcome, Clinical & Experimental Metastasis, 35, 4, 2018. Crossref

  15. Ayla Şule, Öktem Gülperi, Parlayan Cüneyd, ZNF304 gen ifadesinde artış ve CXCR4’de azalma ile prostat kanserinde anoikis değişebilir, Ege Tıp Dergisi, 2019. Crossref

  16. Wudtiwai Benjawan, Pitchakarn Pornsiri, Banjerdpongchai Ratana, Alpha-mangostin, an active compound in Garcinia mangostana, abrogates anoikis-resistance in human hepatocellular carcinoma cells, Toxicology in Vitro, 53, 2018. Crossref

  17. Aghanejad Ayuob, Babamiri Hiwa, Adibkia Khosro, Barar Jaleh, Omidi Yadollah, Mucin-1 aptamer-armed superparamagnetic iron oxide nanoparticles for targeted delivery of doxorubicin to breast cancer cells, BioImpacts, 8, 2, 2018. Crossref

  18. Bregenzer , Horst , Mehta , Novak , Repetto , Mehta , The Role of Cancer Stem Cells and Mechanical Forces in Ovarian Cancer Metastasis, Cancers, 11, 7, 2019. Crossref

  19. Soriano Amata Amy, de Cristofaro Tiziana, Di Palma Tina, Dotolo Serena, Gokulnath Priyanka, Izzo Antonella, Calì Gaetano, Facchiano Angelo, Zannini Mariastella, PAX8 expression in high-grade serous ovarian cancer positively regulates attachment to ECM via Integrin β3, Cancer Cell International, 19, 1, 2019. Crossref

  20. Valavanis Christos, Stanc Gabriela, Long Noncoding RNAs in Osteosarcoma: Mechanisms and Potential Clinical Implications, in Osteosarcoma – Diagnosis, Mechanisms, and Translational Developments, 2019. Crossref

  21. Shi Weiwei, Wang Dongmei, Yuan Xinwang, Liu Yi, Guo Xiaojie, Li Jingsong, Song Jianguo, Shen Zhiyuan, Glucocorticoid receptor–IRS-1 axis controls EMT and the metastasis of breast cancers, Journal of Molecular Cell Biology, 11, 12, 2019. Crossref

  22. You Yuan, Stelzl Patrick, Zhang Yonghong, Porter James, Liu Hong, Liao Ai‐Hua, Aldo Paulomi B., Mor Gil, Novel 3D in vitro models to evaluate trophoblast migration and invasion, American Journal of Reproductive Immunology, 81, 3, 2019. Crossref

  23. Varankar Sagar S, Bapat Sharmila A, Uncoupling Traditional Functionalities of Metastasis: The Parting of Ways with Real-Time Assays, Journal of Clinical Medicine, 8, 7, 2019. Crossref

  24. Wilson Robert B., Solass Wiebke, Archid Rami, Weinreich Frank-Jürgen, Königsrainer Alfred, Reymond Marc A., Resistance to anoikis in transcoelomic shedding: the role of glycolytic enzymes, Pleura and Peritoneum, 4, 1, 2019. Crossref

  25. Akolkar Dadasaheb, Patil Darshana, Crook Timothy, Limaye Sewanti, Page Raymond, Datta Vineet, Patil Revati, Sims Cynthe, Ranade Anantbhushan, Fulmali Pradeep, Fulmali Pooja, Srivastava Navin, Devhare Pradip, Apurwa Sachin, Patel Shoeb, Patil Sanket, Adhav Archana, Pawar Sushant, Ainwale Akshay, Chougule Rohit, Apastamb Madhavi, Srinivasan Ajay, Datar Rajan, Circulating ensembles of tumor‐associated cells: A redoubtable new systemic hallmark of cancer, International Journal of Cancer, 146, 12, 2020. Crossref

  26. Bhatt Akshita B., Gupta Mohit, Hoang Van T., Chakrabarty Suravi, Wright Thomas D., Elliot Steven, Chopra Ishveen K., Monlish Darlene, Anna Katie, Burow Matthew E., Cavanaugh Jane E., Flaherty Patrick T., Novel Diphenylamine Analogs Induce Mesenchymal to Epithelial Transition in Triple Negative Breast Cancer, Frontiers in Oncology, 9, 2019. Crossref

  27. Huang Qi-Yuan, Liu Guo-Feng, Qian Xian-Ling, Tang Li-Bo, Huang Qing-Yun, Xiong Li-Xia, Long Non-Coding RNA: Dual Effects on Breast Cancer Metastasis and Clinical Applications, Cancers, 11, 11, 2019. Crossref

  28. Martin Megan E., Reaves Denise K., Jeffcoat Breanna, Enders Jeffrey R, Costantini Lindsey M., Yeyeodu Susan T., Botta Diane, Kavanagh Terrance J., Fleming Jodie M., Silver nanoparticles alter epithelial basement membrane integrity, cell adhesion molecule expression, and TGF-β1 secretion, Nanomedicine: Nanotechnology, Biology and Medicine, 21, 2019. Crossref

  29. Bougen-Zhukov Nicola, Nouri Yasmin, Godwin Tanis, Taylor Megan, Hakkaart Christopher, Single Andrew, Brew Tom, Permina Elizabeth, Chen Augustine, Black Michael A., Guilford Parry, Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient Cells, Cancers, 11, 9, 2019. Crossref

  30. Bonuccelli Gloria, De Francesco Ernestina Marianna, de Boer Rianne, Tanowitz Herbert B., Lisanti Michael P., NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemness”, Oncotarget, 8, 13, 2017. Crossref

  31. Zhou Xiaoman, Yang Ganglong, Guan Feng, Biological Functions and Analytical Strategies of Sialic Acids in Tumor, Cells, 9, 2, 2020. Crossref

  32. Li Jianxia, Zhang Jianwei, Hu Huabin, Cai Yue, Ling Jiayu, Wu Zehua, Deng Yanhong, <p>Gene Expression Signature to Predict Prognosis and Adjuvant Chemosensitivity of Colorectal Cancer Patients</p>, Cancer Management and Research, Volume 12, 2020. Crossref

  33. Genna Anthony, Vanwynsberghe Aline M., Villard Amélie V., Pottier Charles, Ancel Julien, Polette Myriam, Gilles Christine, EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis, Cancers, 12, 6, 2020. Crossref

  34. Budkova Zuzana, Sigurdardottir Anna Karen, Briem Eirikur, Bergthorsson Jon Thor, Sigurdsson Snævar, Magnusson Magnus Karl, Traustadottir Gunnhildur Asta, Gudjonsson Thorarinn, Hilmarsdottir Bylgja, Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor Cells, Frontiers in Cell and Developmental Biology, 8, 2020. Crossref

  35. Libring Sarah, Shinde Aparna, Chanda Monica K., Nuru Maryam, George Heather, Saleh Aya M., Abdullah Ammara, Kinzer-Ursem Tamara L., Calve Sarah, Wendt Michael K., Solorio Luis, The Dynamic Relationship of Breast Cancer Cells and Fibroblasts in Fibronectin Accumulation at Primary and Metastatic Tumor Sites, Cancers, 12, 5, 2020. Crossref

  36. Jie Xiao-Xiang, Zhang Xiao-Yan, Xu Cong-Jian, Epithelial-to-mesenchymal transition, circulating tumor cells and cancer metastasis: Mechanisms and clinical applications, Oncotarget, 8, 46, 2017. Crossref

  37. Cao Zheng, Koochekpour Shahriar, Strup Stephen E., Kyprianou Natasha, Reversion of epithelial-mesenchymal transition by a novel agent DZ-50 via IGF binding protein-3 in prostate cancer cells, Oncotarget, 8, 45, 2017. Crossref

  38. Shi Yu-Bo, Li Jun, Lai Xing-Ning, Jiang Rui, Zhao Rui-Chen, Xiong Li-Xia, Multifaceted Roles of Caveolin-1 in Lung Cancer: A New Investigation Focused on Tumor Occurrence, Development and Therapy, Cancers, 12, 2, 2020. Crossref

  39. Huang Huaming , Nie Chao , Qin Xiaokang , Zhou Jie , Zhang Lei, Diosgenin inhibits the epithelial‑mesenchymal transition initiation in osteosarcoma cells via the p38MAPK signaling pathway, Oncology Letters, 2019. Crossref

  40. Velotti Francesca, Barchetta Ilaria, Cimini Flavia Agata, Cavallo Maria Gisella, Granzyme B in Inflammatory Diseases: Apoptosis, Inflammation, Extracellular Matrix Remodeling, Epithelial-to-Mesenchymal Transition and Fibrosis, Frontiers in Immunology, 11, 2020. Crossref

  41. Barillari Giovanni, The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process, International Journal of Molecular Sciences, 21, 12, 2020. Crossref

  42. Lim Won-Chul, Choi Jae Woong, Song Nho-Eul, Cho Chang-Won, Rhee Young Kyoung, Hong Hee-Do, Polysaccharide isolated from persimmon leaves (Diospyros kaki Thunb.) suppresses TGF-β1-induced epithelial-to-mesenchymal transition in A549 cells, International Journal of Biological Macromolecules, 164, 2020. Crossref

  43. Crowell Lexi, Yakisich Juan, Aufderheide Brian, Adams Tayloria, Electrical Impedance Spectroscopy for Monitoring Chemoresistance of Cancer Cells, Micromachines, 11, 9, 2020. Crossref

  44. Liu Jiamei, Yang Liyu, Fu Qin, Liu Shengye, Emerging Roles and Potential Biological Value of CircRNA in Osteosarcoma, Frontiers in Oncology, 10, 2020. Crossref

  45. Zhao Bei, Xie Jun, Zhou Xiyuan, Zhang Lixia, Cheng Xiankui, Liang Chenglin, YAP activation in melanoma contributes to anoikis resistance and metastasis, Experimental Biology and Medicine, 246, 8, 2021. Crossref

  46. Sen Plaboni, Saha Muktashree, Ghosh Siddhartha Sankar, Nanoparticle mediated alteration of EMT dynamics: an approach to modulate cancer therapeutics, Materials Advances, 1, 8, 2020. Crossref

  47. Bou-Dargham Mayassa J., Sang Qing-Xiang Amy, Haque Nazmul, Secretome analysis reveals upregulated granzyme B in human androgen-repressed prostate cancer cells with mesenchymal and invasive phenotype, PLOS ONE, 15, 8, 2020. Crossref

  48. Nagl Laurenz, Horvath Lena, Pircher Andreas, Wolf Dominik, Tumor Endothelial Cells (TECs) as Potential Immune Directors of the Tumor Microenvironment – New Findings and Future Perspectives, Frontiers in Cell and Developmental Biology, 8, 2020. Crossref

  49. Krajewski Adrian, Gagat Maciej, Mikołajczyk Klaudia, Izdebska Magdalena, Żuryń Agnieszka, Grzanka Alina, Cyclin F Downregulation Affects Epithelial-Mesenchymal Transition Increasing Proliferation and Migration of the A-375 Melanoma Cell Line, Cancer Management and Research, Volume 12, 2020. Crossref

  50. Jiang Shasha, Mao Chunguo, Jiang Bin, Tan Qunyou, Deng Bo, High Expression of BCAR1 by Circulating Tumor Cells and Tumor Tissues Is Predictive of a Poor Prognosis of Early-Stage Lung Adenocarcinoma Potentially Due to Regulation of Epithelial-Mesenchymal Transition, Technology in Cancer Research & Treatment, 19, 2020. Crossref

  51. Archer Maddison, Kyprianou Natasha, Homeless Cells Escape Death and Deliver Lethal Cancer, Endocrinology, 162, 4, 2021. Crossref

  52. Peyre Ludovic, Meyer Mickael, Hofman Paul, Roux Jérémie, TRAIL receptor-induced features of epithelial-to-mesenchymal transition increase tumour phenotypic heterogeneity: potential cell survival mechanisms, British Journal of Cancer, 124, 1, 2021. Crossref

  53. Vuoso Daniela Cristina, D’Angelo Stefania, Ferraro Rosalia, Caserta Sergio, Guido Stefano, Cammarota Marcella, Porcelli Marina, Cacciapuoti Giovanna, Annurca apple polyphenol extract promotes mesenchymal-to-epithelial transition and inhibits migration in triple-negative breast cancer cells through ROS/JNK signaling, Scientific Reports, 10, 1, 2020. Crossref

  54. Ecoy Gea Abigail Uy, Chamni Supakarn, Suwanborirux Khanit, Chanvorachote Pithi, Chaotham Chatchai, Jorunnamycin A from Xestospongia sp. Suppresses Epithelial to Mesenchymal Transition and Sensitizes Anoikis in Human Lung Cancer Cells, Journal of Natural Products, 82, 7, 2019. Crossref

  55. Cagle Patrice, Smith Nikia, Adekoya Timothy O., Li Yahui, Kim Susy, Rios-Colon Leslimar, Deep Gagan, Niture Suryakant, Albanese Christopher, Suy Simeng, Collins Sean P., Kumar Deepak, Knockdown of microRNA-214-3p Promotes Tumor Growth and Epithelial-Mesenchymal Transition in Prostate Cancer, Cancers, 13, 23, 2021. Crossref

  56. Guberman Eric, Sherief Hikmet, Regan Erzsébet Ravasz, Boolean model of anchorage dependence and contact inhibition points to coordinated inhibition but semi-independent induction of proliferation and migration, Computational and Structural Biotechnology Journal, 18, 2020. Crossref

  57. Xing Cheng, Li Yatong, Ding Cheng, Wang Shunda, Zhang Hanyu, Chen Lixin, Li Pengyu, Dai Menghua, CD44+ Circulating Tumor Endothelial Cells Indicate Poor Prognosis in Pancreatic Ductal Adenocarcinoma After Radical Surgery: A Pilot Study, Cancer Management and Research, Volume 13, 2021. Crossref

  58. Kim Dae Kyoung, Kim Yu Na, Kim Ye Eun, Lee Seo Yul, Shin Min Joo, Do Eun Kyoung, Choi Kyung-Un, Kim Seung-Chul, Kim Ki-Hyung, Suh Dong-Soo, Song Parkyong, Kim Jae Ho, TRIB2 Stimulates Cancer Stem-Like Properties through Activating the AKT-GSK3β-β-Catenin Signaling Axis, Molecules and Cells, 44, 7, 2021. Crossref

  59. Bhatt Akshita B., Wright Thomas D., Barnes Van, Chakrabarty Suravi, Matossian Margarite D., Lexner Erin, Ucar Deniz A., Miele Lucio, Flaherty Patrick T., Burow Matthew E., Cavanaugh Jane E., Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer, Translational Oncology, 14, 6, 2021. Crossref

  60. Jiang Sha-Sha, Mao Chun-Guo, Feng Yong-Geng, Jiang Bin, Tao Shao-Lin, Tan Qun-You, Deng Bo, Circulating tumor cells with epithelial-mesenchymal transition markers as potential biomarkers for the diagnosis of lung cancer, World Journal of Clinical Cases, 9, 12, 2021. Crossref

  61. Yufei Zheng, Yuqi Wu, Binyue Hu, Lingchen Tao, Xi Chen, Hoffelt Dixon, Fuliang Hu, Chrysin Inhibits Melanoma Tumor Metastasis via Interfering with the FOXM1/β-Catenin Signaling, Journal of Agricultural and Food Chemistry, 68, 35, 2020. Crossref

  62. Rutherford Taylor R., Elder Alan M., Lyons Traci R., Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a, Cell Death & Disease, 12, 10, 2021. Crossref

  63. Gonçalves Diego Assis, Jasiulionis Miriam Galvonas, Melo Fabiana Henriques Machado de, The Role of the BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin, International Journal of Molecular Sciences, 22, 17, 2021. Crossref

  64. Patra Tapas, Bose Sandip K., Kwon Young-Chan, Meyer Keith, Ray Ranjit, Inhibition of p70 isoforms of S6K1 induces anoikis to prevent transformed human hepatocyte growth, Life Sciences, 265, 2021. Crossref

  65. Juan Zhang, Dake Chu, Tanaka Kiyohito, Shuixiang He, EGFL7 as a novel therapeutic candidate regulates cell invasion and anoikis in colorectal cancer through PI3K/AKT signaling pathway, International Journal of Clinical Oncology, 26, 6, 2021. Crossref

  66. Yu Li, Wang Xin, Du Yao, Zhang Xiaowen, Ling Yunzhi, Hawinkels Lukas J.A.C., FASN Knockdown Inhibited Anoikis Resistance of Gastric Cancer Cells via P-ERK1/2/Bcl-xL Pathway, Gastroenterology Research and Practice, 2021, 2021. Crossref

  67. Zheng Jia-Lu, Wang Shuang-Shuang, Shen Ke-Ping, Chen Lei, Peng Xiao, Chen Jin-Fang, An Hong-Mei, Hu Bing, Ursolic acid induces apoptosis and anoikis in colorectal carcinoma RKO cells, BMC Complementary Medicine and Therapies, 21, 1, 2021. Crossref

  68. Ikeda Tsunehiko, Nakamura Kimitoshi, Sato Takaki, Kida Teruyo, Oku Hidehiro, Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance, International Journal of Molecular Sciences, 22, 4, 2021. Crossref

  69. Kryvoshlyk I., CIRCULATING TUMOR CELLS: WHERE WE LEFT OFF?, Biotechnologia Acta, 14, 4, 2021. Crossref

  70. Altschuler Joshua, Stockert Jennifer A., Kyprianou Natasha, Non-Coding RNAs Set a New Phenotypic Frontier in Prostate Cancer Metastasis and Resistance, International Journal of Molecular Sciences, 22, 4, 2021. Crossref

  71. Jonckheere Sven, Adams Jamie, De Groote Dominic, Campbell Kyra, Berx Geert, Goossens Steven, Epithelial-Mesenchymal Transition (EMT) as a Therapeutic Target, Cells Tissues Organs, 211, 2, 2022. Crossref

  72. Wagner Johanna, Masek Markus, Jacobs Andrea, Soneson Charlotte, Sivapatham Sujana, Damond Nicolas, de Souza Natalie, Robinson Mark D., Bodenmiller Bernd, Mass cytometric and transcriptomic profiling of epithelial-mesenchymal transitions in human mammary cell lines, Scientific Data, 9, 1, 2022. Crossref

  73. Wang Yen-Yun, Hung Amos C., Lo Steven, Yuan Shyng-Shiou F., Adipocytokines visfatin and resistin in breast cancer: Clinical relevance, biological mechanisms, and therapeutic potential, Cancer Letters, 498, 2021. Crossref

  74. Qi Xiaochen, Li Quanlin, Che Xiangyu, Wang Qifei, Wu Guangzhen, Application of Regulatory Cell Death in Cancer: Based on Targeted Therapy and Immunotherapy, Frontiers in Immunology, 13, 2022. Crossref

  75. Corsi Francesca, Capradossi Francesco, Pelliccia Andrea, Briganti Stefania, Bruni Emanuele, Traversa Enrico, Torino Francesco, Reichle Albrecht, Ghibelli Lina, Apoptosis as Driver of Therapy-Induced Cancer Repopulation and Acquired Cell-Resistance (CRAC): A Simple In Vitro Model of Phoenix Rising in Prostate Cancer, International Journal of Molecular Sciences, 23, 3, 2022. Crossref

  76. Chen Lin-Yu, Huang Rui-Lan, Su Po-Hsuan, Chu Ling-Hui, Weng Yu-Chun, Wang Hui-Chen, Lai Hung-Cheng, Wen Kuo-Chang, Epigenomic Profiling of Epithelial Ovarian Cancer Stem-Cell Differentiation Reveals GPD1 Associated Immune Suppressive Microenvironment and Poor Prognosis, International Journal of Molecular Sciences, 23, 9, 2022. Crossref

  77. Brabletz Simone, Schuhwerk Harald, Brabletz Thomas, Stemmler Marc P., Dynamic EMT: a multi‐tool for tumor progression, The EMBO Journal, 40, 18, 2021. Crossref

  78. Tan Xiaochao, Banerjee Priyam, Shi Lei, Xiao Guan-Yu, Rodriguez B. Leticia, Grzeskowiak Caitlin L., Liu Xin, Yu Jiang, Gibbons Don L., Russell William K., Creighton Chad J., Kurie Jonathan M., p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi, Science Advances, 7, 25, 2021. Crossref

  79. Frisch Steven M., Anoikis, 2022, in Reference Module in Life Sciences, 2022. Crossref

  80. Shonibare Zainab, Monavarian Mehri, O’Connell Kathleen, Altomare Diego, Shelton Abigail, Mehta Shubham, Jaskula-Sztul Renata, Phaeton Rebecca, Starr Mark D., Whitaker Regina, Berchuck Andrew, Nixon Andrew B., Arend Rebecca C., Lee Nam Y., Miller C. Ryan, Hempel Nadine, Mythreye Karthikeyan, Reciprocal SOX2 regulation by SMAD1-SMAD3 is critical for anoikis resistance and metastasis in cancer, Cell Reports, 40, 4, 2022. Crossref

  81. Goulioumis Anastasios, Gyftopoulos Kostis, Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma, Biomedicines, 10, 9, 2022. Crossref

  82. Zhevlakova Irina, Xiong Luyang, Liu Huan, Dudiki Tejasvi, Ciocea Alieta, Podrez Eugene, Byzova Tatiana V., Opposite roles of Kindlin orthologs in cell survival and proliferation, Cell Proliferation, 55, 9, 2022. Crossref

  83. Huang Yuhe, Hong Weiqi, Wei Xiawei, The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis, Journal of Hematology & Oncology, 15, 1, 2022. Crossref

  84. Alhaddad Lina, Osipov Andreyan N., Leonov Sergey, The Molecular and Cellular Strategies of Glioblastoma and Non-Small-Cell Lung Cancer Cells Conferring Radioresistance, International Journal of Molecular Sciences, 23, 21, 2022. Crossref

  85. Karagiorgou Zoi, Fountas Panagiotis N., Manou Dimitra, Knutsen Erik, Theocharis Achilleas D., Proteoglycans Determine the Dynamic Landscape of EMT and Cancer Cell Stemness, Cancers, 14, 21, 2022. Crossref

  86. Zhang Yao-Yu, Li Xiao-Wei, Li Xiao-Dong, Zhou Ting-Ting, Chen Chao, Liu Ji-Wen, Wang Li, Jiang Xin, Wang Liang, Liu Ming, Zhao You-Guang, Li Sha-dan, Comprehensive analysis of anoikis-related long non-coding RNA immune infiltration in patients with bladder cancer and immunotherapy, Frontiers in Immunology, 13, 2022. Crossref

  87. Yu Guiping, Chen Yiqi, Hu Yuwen, Zhou Yan, Ding Xiaoling, Zhou Xiaorong, Roles of transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation, Frontiers in Cell and Developmental Biology, 10, 2022. Crossref

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