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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Imprimer: 0893-9675
ISSN En ligne: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v5.i2-3.40
pages 169-199

Retroviral Determinants of Leukemogenesis

Grace B. Athas
Department of Microbiology and Immunology SL-38; Tulane Cancer Center SL-68, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana 70112
Cindi R. Starkey
Tulane Cancer Center SL-68; and Program in Molecular and Cellular Biology SL-79, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana 70112
Laura S. Levy
Department of Microbiology and Immunology SL-38; Tulane Cancer Center SL-68; and Program in Molecular and Cellular Biology SL-79, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana 70112

RÉSUMÉ

The slowly transforming, leukemogenic retroviruses of humans and other mammals induce malignant disease after prolonged latency but lack an oncogene to which their malignant potential can be attributed directly. The leukemogenic activity of these retroviruses can be attributed to at least three factors, including (1) transcriptional regulatory sequences in the long terminal repeat; (2) the insertional mutagenesis of cellular protooncogenes, thus activating their malignant potential; and (3) the actions of structural and regulatory proteins encoded by viral genes. The goal of this review is to summarize recent findings regarding the roles of these factors in retroviral leukemogenesis. The focus of the review is on the slowly transforming, leukemogenic retroviruses of mammals, including humans and experimental animals.


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