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Critical Reviews™ in Oncogenesis

Publication de 4  numéros par an

ISSN Imprimer: 0893-9675

ISSN En ligne: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Rat Tumor Cytogenetics: A Critical Evaluation of the Literature

Volume 5, Numéro 2-3, 1994, pp. 271-295
DOI: 10.1615/CritRevOncog.v5.i2-3.80
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RÉSUMÉ

Cancer cytogenetics is a valuable tool for the analysis of cellular and molecular aberrations during malignant transformation and tumor progression. The rat has served as an important experimental model to investigate various steps in oncogenesis. An attempt was made to compile data on rat tumor cytogenetics from previously published data in order to provide a basis for further research, especially when combining classic and molecular cytogenetics, a yet underdeveloped area of research in rat tumorigenesis. The wealth of data presented here provides a contrast to its impact on biological specificity. Because of the different experimental procedures involved with tumor induction and the application of carcinogens at relatively high dosages, as well as occasional less than careful histological documentation, a delineation of unambiguous chromosome alterations, critical in the process of carcinogenesis, is rare in the rat. Future studies should be performed with spontaneously arising rat tumors and/or tumors after low, single-dose carcinogen exposure in order to reduce unspecific karyotype alterations not intrinsically related to tumor initiation and progression. Short-term culture or early passages in vitro should be methods of choice, especially for solid tumors, to avoid erroneous karyotype analyses because of contaminating normal cells. The combined karyological and molecular genetic approach to an analysis of tumor-specific changes, still hindered by an almost complete lack of cell type-, chromosome-, or gene-specific molecular probes for the rat, should become a focus of research in order to continue having the advantages this species offers for stage-specific analysis of tumorigenesis.

CITÉ PAR
  1. Bolon Brad, Galbreath Elizabeth, Sargent Linda, Weiss Jürgen, Genetic Engineering and Molecular Technology, in The Laboratory Rat, 2000. Crossref

  2. - management, in The Laboratory Rat, 2012. Crossref

  3. Kerler Rosi, Rabes Hartmut M., Karyotype evolution of the clonal rat liver cell line CL 52 during progression in vitro and in vivo, Cancer Genetics and Cytogenetics, 87, 2, 1996. Crossref

  4. Laurent Dano, Guilly Marie-Noëlle, Dutrillaux Bernard, Chevillard Sylvie, Clonal evolution of a radon-induced rat lung tumor, Cancer Genetics and Cytogenetics, 125, 1, 2001. Crossref

  5. Popescu Nicholas C., Greiner John W., Recurrent alterations of the short arm of chromosome 3 define a tumor suppressor region in rat mammary tumor cells , Carcinogenesis, 20, 10, 1999. Crossref

  6. Koelsch Bernd U., Kindler-Röhrborn Andrea, Held Sabine, Zabel Simone, Rajewsky Manfred F., Loss of heterozygosity in malignant rat schwannomas chemically induced in hybrids of inbred rat strains with differential tumor susceptibility, Carcinogenesis, 23, 6, 2002. Crossref

  7. Sugiyama Taketoshi, Osaka Mitsuhiko, Koami Kenichi, Maeda Sakan, Ueda Norifumi, 7,12-DMBA-induced rat leukemia: a review with insights into future research, Leukemia Research, 26, 12, 2002. Crossref

  8. Palmer Theo D., Takahashi Jun, Gage Fred H., The Adult Rat Hippocampus Contains Primordial Neural Stem Cells, Molecular and Cellular Neuroscience, 8, 6, 1997. Crossref

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