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Plasma Medicine
SJR: 0.278 SNIP: 0.183 CiteScore™: 0.57

ISSN Imprimer: 1947-5764
ISSN En ligne: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2013006218
pages 71-83

Deep Penetration into Tissues of Reactive Oxygen Species Generated in Floating-Electrode Dielectric Barrier Discharge (FE-DBD): An In Vitro Agarose Gel Model Mimicking an Open Wound

Danil Dobrynin
C&J Nyheim Plasma Institute, Drexel University, Camden NJ 08103
Gregory Fridman
C&J Nyheim Plasma Institute, Drexel University, Camden, New Jersey 08103
Gary Friedman
Department of Electrical and Computer Engineering, College of Engineering, A. J. Drexel Plasma Institute, Drexel University, Philadelphia, Pennsylvania
Alexander A. Fridman
C&J Nyheim Plasma Institute, Drexel University, Camden, New Jersey 08103

RÉSUMÉ

In this article we present an in vitro model based on agarose gel that can be used to simulate a dirty, oily, bloody, and morphologically complex surface of, for example, an open wound. We show this model's effectiveness in simulating the depth of penetration of reactive species generated in plasma (e.g., hydrogen peroxide) deep into the tissue of a rat and confirm the penetration depths using an agarose gel model. We envision that such a model could be used in the future to study plasma discharges (and other modalities) and minimize the use of live animals; plasma can be optimized on the agarose gel wound model and then finally verified using an actual wound.