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Plasma Medicine

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ISSN Imprimer: 1947-5764

ISSN En ligne: 1947-5772

SJR: 0.216 SNIP: 0.263 CiteScore™:: 1.4 H-Index: 24

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Nanosecond-Pulsed Dielectric Barrier Discharge–Induced Antitumor Effects Propagate through Depth of Tissue via Intracellular Signaling

Volume 7, Numéro 3, 2017, pp. 283-297
DOI: 10.1615/PlasmaMed.2017019883
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RÉSUMÉ

Studies using xenograft mouse models have shown that plasma applied to the skin overlying tumors results in tumor shrinkage. Plasma is considered a nonpenetrating treatment; however, these studies demonstrate plasma effects that occur beyond the postulated depth of physical penetration of plasma components. The present study examines the propagation of plasma effects through a tissue model using three-dimensional, cell-laden extracellular matrices (ECMs). These ECMs are used as barriers against direct plasma penetration. By placing them onto a monolayer of target cancer cells to create an in-vitro analog to in-vivo studies, we distinguished between cellular effects from direct plasma exposure and cellular effects due to cell-to-cell signaling stimulated by plasma. We show that nanosecond-pulsed dielectric barrier discharge plasma treatment applied atop an acellular barrier impedes the externalization of calreticulin (CRT) in the target cells. In contrast, when a barrier is populated with cells, CRT externalization is restored. Thus, we demonstrate that plasma components stimulate signaling among cells embedded in the barrier to transfer plasma effects to the target cells.

CITÉ PAR
  1. Lin Abraham, Truong Billy, Patel Sohil, Kaushik Nagendra, Choi Eun, Fridman Gregory, Fridman Alexander, Miller Vandana, Nanosecond-Pulsed DBD Plasma-Generated Reactive Oxygen Species Trigger Immunogenic Cell Death in A549 Lung Carcinoma Cells through Intracellular Oxidative Stress, International Journal of Molecular Sciences, 18, 5, 2017. Crossref

  2. Lin Abraham G., Xiang Bo, Merlino Dante J., Baybutt Trevor R., Sahu Joya, Fridman Alexander, Snook Adam E., Miller Vandana, Non-thermal plasma induces immunogenic cell deathin vivoin murine CT26 colorectal tumors, OncoImmunology, 7, 9, 2018. Crossref

  3. Katiyar Kritika S., Lin Abraham, Fridman Alexander, Keating Carolyn E., Cullen D. Kacy, Miller Vandana, Non-Thermal Plasma Accelerates Astrocyte Regrowth and Neurite Regeneration Following Physical Trauma In Vitro, Applied Sciences, 9, 18, 2019. Crossref

  4. Mohamed Hager, Esposito Rita A., Kutzler Michele A., Wigdahl Brian, Krebs Fred C., Miller Vandana, Nonthermal plasma as part of a novel strategy for vaccination, Plasma Processes and Polymers, 17, 10, 2020. Crossref

  5. Mohamed Hager, Nayak Gaurav, Rendine Nicole, Wigdahl Brian, Krebs Fred C., Bruggeman Peter J., Miller Vandana, Non-Thermal Plasma as a Novel Strategy for Treating or Preventing Viral Infection and Associated Disease, Frontiers in Physics, 9, 2021. Crossref

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