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Computational Thermal Sciences: An International Journal
ESCI SJR: 0.249 SNIP: 0.434 CiteScore™: 0.7

ISSN Imprimer: 1940-2503
ISSN En ligne: 1940-2554

Computational Thermal Sciences: An International Journal

DOI: 10.1615/ComputThermalScien.2012006531
pages 457-475

LASER INDUCED HYPERTHERMIA OF SUPERFICIAL TUMORS: A TRANSIENT THERMAL MODEL FOR INDIRECT HEATING STRATEGY

Victoria Timchenko
School of Mechanical and Manufacturing Engineering, The University of New South Wales, Sydney 2052, Australia
Leonid A. Dombrovsky
Joint Institute for High Temperatures, 17A Krasnokazarmennaya Str., Moscow, 111116, Russia; Tyumen State University, 6 Volodarsky Str., Tyumen, 625003, Russia
National Committee of Heat and Mass Transfer (NCHMT)

RÉSUMÉ

An indirect heating strategy based on laser irradiation of surrounding tissues as an alternative to a direct irradiation of superficial tumors is presented in this paper. The computational analysis is based on two-dimensional axisymmetric models for both radiative transfer and transient heat transfer in a human body Coupled transient energy equations for composite human tissue take into account the metabolic heat generation and heat conduction, blood perfusion through capillaries, the volumetric heat transfer between arterial blood and ambient tissue, the periodic laser heating, and also heat transfer between the human body and ambient medium. The relative role of the treatment parameters on the transient temperature field and degree of thermal conversions in human tissues has been studied by solving an example problem for a superficial human cancer with and without embedded gold nanoshells. The thermal conversions in blood and tumor tissue as a response to hyperthermia are estimated by solving Arrhenius-type kinetic equations. It is shown that required parameters for hyperthermia treatment can be attained without gold nanoshells.


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