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Atomization and Sprays

Publication de 12  numéros par an

ISSN Imprimer: 1044-5110

ISSN En ligne: 1936-2684

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00095 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.28 SJR: 0.341 SNIP: 0.536 CiteScore™:: 1.9 H-Index: 57

Indexed in

EXPERIMENTAL INVESTIGATION OF ENDOSCOPIC CELL SPRAY

Volume 27, Numéro 10, 2017, pp. 847-858
DOI: 10.1615/AtomizSpr.2017020134
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RÉSUMÉ

Stem cell therapy requires high local concentration of living cells at the area of treatment. An innovative approach aims at high local cell concentrations in hollow organs by application of cells through flexible endoscopy. The endoscope's working channel is equipped with a catheter nozzle for coaxial liquid atomization of cell suspensions. Until now, little information is available regarding the influence of atomization parameters on cell survival and the influence of cells in solution on atomization. Therefore, a parametric study on atomization of cell suspensions is performed in this work. The mutual interaction of cells and atomization is experimentally analyzed, aiming at a correlation between air Reynolds number, droplet sizes, and cell survival rates. The influences of catheter flow, atomization, and droplet wall interaction on cell survival are quantified and thus the extensional flow during ligament formation is identified as main cell destruction mechanism. On the basis of the present endoscopic configuration, integral cell survival rates above 80% are achieved. Thus, it offers the opportunity for homogeneous local distribution of cells in hollow cavities.

CITÉ PAR
  1. Thiebes Anja Lena, Klein Sarah, Zingsheim Jonas, Möller Georg H., Gürzing Stefanie, Reddemann Manuel A., Behbahani Mehdi, Jockenhoevel Stefan, Cornelissen Christian G., Effervescent Atomizer as Novel Cell Spray Technology to Decrease the Gas-to-Liquid Ratio, Pharmaceutics, 14, 11, 2022. Crossref

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