Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 1.734 Facteur d'impact sur 5 ans: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v22.i4.60
pages 325-343

Monogenic and Complex Forms of Obesity: Insights from Genetics Reveal the Leptin-Melanocortin Signaling Pathway as a Common Player

Doreen Zegers
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
Wim Van Hul
Department of Medical Genetics, University of Antwerp (UA) and Department of Medical Genetics, University Hospital of Antwerp (UZA)
Luc F. Van Gaal
Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Antwerp
Sigri Beckers
Department of Medical Genetics, University of Antwerp, Antwerp, Belgium

RÉSUMÉ

The role of genetic factors involved in the etiology of human obesity is beyond question. The identification of the hypothalamic leptin-melanocortin signaling pathway as a critical regulator in energy homeostasis and food intake has been essential for genetic research. In this review, we discuss the involvement of established and novel genes from this pathway in the pathogenesis of obesity. Their roles in monogenic and complex forms of obesity are illustrated by discussing the results of mutation analysis, candidate gene and genome-wide association studies, as well as copy number analysis. While we can conclude from these outcomes that the leptin-melanocortin pathway is of immense importance, there is still a lot of heritability that currently cannot be explained. Future studies implementing genome-wide association studies, genome-wide copy number variant analysis, and whole exome and whole-genome sequencing might aid in finding new variation in the conventional pathways and might reveal new biological pathways implicated in the pathogenesis of obesity.


Articles with similar content:

Oncogenic Signaling Pathways and Pathway-Based Therapeutic Biomarkers in Lymphoid Malignancies
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 5-6
Ruifang Sun, Ken H. Young, Jinfen Wang
Functional Role of MicroRNAs in Prostate Cancer and Therapeutic Opportunities
Critical Reviews™ in Oncogenesis, Vol.18, 2013, issue 4
Marcello Maugeri-Sacca, Valeria Coppola, Ruggero De Maria, Desiree Bonci
Cancer and Cancer Stem Cells: New Molecular Perspectives
Critical Reviews™ in Oncogenesis, Vol.24, 2019, issue 1
Onur Sahin, Gokce Ceren Kuscu, Gulperi Oktem, Elif Tunc, Funda Cagirir Dindaroglu, Cevik Gurel, Ismet Hortu, Gizem Inetas, Aylin Buhur
The Role of the Leptin-Melanocortin Signalling Pathway in the Control of Food Intake
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 4
Doreen Zegers, Sigri Beckers, Luc F. Van Gaal, Wim Van Hul
Genome Instability in the Context of Chromatin Structure and Fragile Sites
Critical Reviews™ in Eukaryotic Gene Expression, Vol.20, 2010, issue 3
Eva Bartova, Gabriela Galiova, Sona Legartova, Alzbeta Jugova, Lenka Stixova, Stanislav Kozubek