Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 1.841 Facteur d'impact sur 5 ans: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v20.i4.20
pages 295-311

FGF Signaling in Craniofacial Biological Control and Pathological Craniofacial Development

Nan E. Hatch
Department of Orthodontics and Pediatric Dentistry, University of Michigan, USA

RÉSUMÉ

Fibroblast growth factor receptors comprise a family of four evolutionarily conserved transmembrane proteins (FGFR1, FGFR2, FGFR3 and FGFR4) known to be critical for the normal development of multiple organ systems. In this review we will primarily focus upon the role of FGF/FGFR signaling as it influences the development of the craniofacial skeleton. Signaling by FGF receptors is regulated by the tissue-specific expression of FGFR isoforms, receptor subtype specific fibroblast growth factors and heparin sulfate proteoglycans. Signaling can also be limited by the expression of endogenous inhibitors. Gain-of-function mutations in FGFRs are associated with a series of congenital abnormality syndromes referred to as the craniosynostosis syndromes. Craniosynostosis is the clinical condition of premature cranial bone fusion and patients who carry craniosynostosis syndrome-associated mutations in FGFRs commonly have abnormalities of the skull vault in the form of craniosynostosis. Patients may also have abnormalities in the facial skeleton, vertebrae and digits. In this review we will discuss recent in vitro and in vivo studies investigating biologic mechanisms by which signaling through FGFRs influences skeletal development and can lead to craniosynostosis.


Articles with similar content:

Tissue-Specific Transformation by Oncogenic Mutants of Epidermal Growth Factor Receptor
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 4
H. J. Kung, T. H. Carter
Steel Factor and c-kit Protooncogene: Genetic Lessons in Signal Transduction
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 2-3
Janna M. Blechman, David Givol, Yosef Yarden, Sima Lev
Aberrant B-Raf Signaling in Human Cancer − 10 Years from Bench to Bedside
Critical Reviews™ in Oncogenesis, Vol.17, 2012, issue 1
Michael Roring, Tilman Brummer
The Cbl Protooncogene Product: From an Enigmatic Oncogene to Center Stage of Signal Transduction
Critical Reviews™ in Oncogenesis, Vol.8, 1997, issue 2-3
Patrice Douillard, Mark L. Lupher, Jr., Nancy L. Lill, Satoshi Ota, Christopher E. Andoniou, Hamid Band, Navin Rao, Sachiko Miyake
Regulation and Regulatory Role of the Retinoids
Critical Reviews™ in Eukaryotic Gene Expression, Vol.5, 1995, issue 3-4
Shehnaaz Manji, T. John Martin, Hong Zhou, Kong Wan Ng