Publication de 6 numéros par an
ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502
Indexed in
Functional Roles of Osteoactivin in Normal and Disease Processes
RÉSUMÉ
Osteoactivin (OA) protein was discovered in bone cells a decade ago. Recent literature suggests that osteoactivin is crucial for the differentiation and functioning of different cell types, including bone-forming osteoblasts and bone-resorbing osteoclast cells. Here, we review the literature to date on various regulatory functions of osteoactivin, as well as its discovery, structure, expression, and function in different tissues and cells. The transcriptional regulation of osteoactivin and its mechanism of action in normal and diseased conditions with special emphasis on bone are also covered in this review. In addition, we touch on the therapeutic potential of osteoactivin in cancer and bone diseases.
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Abdelmagid Samir M., Belcher Joyce Y., Moussa Fouad M., Lababidi Suzanne L., Sondag Gregory R., Novak Kimberly M., Sanyurah Afif S., Frara Nagat A., Razmpour Roshanak, Del Carpio-Cano Fabiola E., Safadi Fayez F., Mutation in Osteoactivin Decreases Bone Formation in Vivo and Osteoblast Differentiation in Vitro, The American Journal of Pathology, 184, 3, 2014. Crossref
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Moussa Fouad M., Hisijara Israel Arango, Sondag Gregory R., Scott Ethan M., Frara Nagat, Abdelmagid Samir M., Safadi Fayez F., Osteoactivin Promotes Osteoblast Adhesion Through HSPG and αvβ1 Integrin, Journal of Cellular Biochemistry, 115, 7, 2014. Crossref
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Girardi C., De Pittà C., Casara S., Calura E., Romualdi C., Celotti L., Mognato M., Integration Analysis of MicroRNA and mRNA Expression Profiles in Human Peripheral Blood Lymphocytes Cultured in Modeled Microgravity, BioMed Research International, 2014, 2014. Crossref
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Vlasakova Katerina, Erdos Zoltan, Troth Sean P., McNulty Kathleen, Chapeau-Campredon Valérie, Mokrzycki Nathalie, Muniappa Nagaraja, Gu Yi-Zhong, Holder Daniel, Bailey Wendy J., Sistare Frank D., Glaab Warren E., Evaluation of the Relative Performance of 12 Urinary Biomarkers for Renal Safety Across 22 Rat Sensitivity and Specificity Studies, Toxicological Sciences, 138, 1, 2014. Crossref
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Sondag Gregory R., Salihoglu Sibel, Lababidi Suzanne L., Crowder Douglas C., Moussa Fouad M., Abdelmagid Samir M., Safadi Fayez F., Osteoactivin Induces Transdifferentiation of C2C12 Myoblasts Into Osteoblasts, Journal of Cellular Physiology, 229, 7, 2014. Crossref
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Fiorentini Chiara, Bodei Serena, Bedussi Francesca, Fragni Martina, Bonini Sara Anna, Simeone Claudio, Zani Danilo, Berruti Alfredo, Missale Cristina, Memo Maurizio, Spano PierFranco, Sigala Sandra, GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity, Experimental Cell Research, 323, 1, 2014. Crossref
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Lee Keun-Ho, Lee Hee-Woo, Choi Hee Jung, Min Hye-jin, Baek Sun Yong, Yoon Sik, Expression and Characterization of Genes by Expressed Sequence Tag Analysis in the Rat Thymus during Regeneration following Acute Thymic Involution Induced by Cyclophosphamide, Korean Journal of Physical Anthropology, 27, 4, 2014. Crossref
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Katayama Akihiro, Nakatsuka Atsuko, Eguchi Jun, Murakami Kazutoshi, Teshigawara Sanae, Kanzaki Motoko, Nunoue Tomokazu, Hida Kazuyuki, Wada Nozomu, Yasunaka Tetsuya, Ikeda Fusao, Takaki Akinobu, Yamamoto Kazuhide, Kiyonari Hiroshi, Makino Hirofumi, Wada Jun, Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis, Scientific Reports, 5, 1, 2015. Crossref
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Frara Nagat, Abdelmagid Samir M., Sondag Gregory R., Moussa Fouad M., Yingling Vanessa R., Owen Thomas A., Popoff Steven N., Barbe Mary F., Safadi Fayez F., Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo, Journal of Cellular Physiology, 231, 1, 2016. Crossref
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Nagahara Yuki, Shimazawa Masamitsu, Tanaka Hirotaka, Ono Yoko, Noda Yasuhiro, Ohuchi Kazuki, Tsuruma Kazuhiro, Katsuno Masahisa, Sobue Gen, Hara Hideaki, Glycoprotein nonmetastatic melanoma protein B ameliorates skeletal muscle lesions in a SOD1G93Amouse model of amyotrophic lateral sclerosis, Journal of Neuroscience Research, 93, 10, 2015. Crossref
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Nagahara Yuki, Shimazawa Masamitsu, Ohuchi Kazuki, Ito Junko, Takahashi Hitoshi, Tsuruma Kazuhiro, Kakita Akiyoshi, Hara Hideaki, GPNMB ameliorates mutant TDP-43-induced motor neuron cell death, Journal of Neuroscience Research, 95, 8, 2017. Crossref
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Almeida Camila F, Martins Poliana CM, Vainzof Mariz, Comparative transcriptome analysis of muscular dystrophy models Largemyd, Dmdmdx/Largemyd and Dmdmdx: what makes them different?, European Journal of Human Genetics, 24, 9, 2016. Crossref
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Yu Bing, Sondag Gregory R., Malcuit Christopher, Kim Min-Ho, Safadi Fayez F., Macrophage-Associated Osteoactivin/GPNMB Mediates Mesenchymal Stem Cell Survival, Proliferation, and Migration Via a CD44-Dependent Mechanism, Journal of Cellular Biochemistry, 117, 7, 2016. Crossref
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Katayama Akihiro, The 2015 Incentive Award of the Okayama Medical Association in General Medical Science (2015 Yuuki Prize), Okayama Igakkai Zasshi (Journal of Okayama Medical Association), 128, 2, 2016. Crossref
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Taya Manisha, Hammes Stephen R., Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB) and Cancer: A Novel Potential Therapeutic Target, Steroids, 133, 2018. Crossref
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Peck Sun H., Tobias John W., Shore Eileen M., Malhotra Neil R., Haskins Mark E., Casal Margret L., Smith Lachlan J., Molecular profiling of failed endochondral ossification in mucopolysaccharidosis VII, Bone, 128, 2019. Crossref
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Guo Kangkang, Xu Lei, Wu Mengmeng, Hou Yufeng, Jiang Yanfen, Lv Jiangman, Xu Panpan, Fan Zhixin, Zhang Ruiqi, Xing Fushan, Zhang Yanming, A Host Factor GPNMB Restricts Porcine Circovirus Type 2 (PCV2) Replication and Interacts With PCV2 ORF5 Protein, Frontiers in Microbiology, 9, 2019. Crossref
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Li Yijun, Yuan Shanshan, Liu Jiaming, Wang Yu, Zhang Yanting, Chen Xiaolu, Si Wangli, CSE1L silence inhibits the growth and metastasis in gastric cancer by repressing GPNMB via positively regulating transcription factor MITF, Journal of Cellular Physiology, 235, 3, 2020. Crossref
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Yao Kunhou, Wei Lunshou, Zhang Junjie, Wang Chenyu, Wang Chaoyang, Qin Changjiang, Li Song, Prognostic values of GPNMB identified by mining TCGA database and STAD microenvironment, Aging, 12, 16, 2020. Crossref
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Lettieri Christina K, Appel Nicole, Labban Nicole, Lussier Danielle M, Blattman Joseph N, Hingorani Pooja, Progress and opportunities for immune therapeutics in osteosarcoma, Immunotherapy, 8, 10, 2016. Crossref
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Cherian Preethi, Al-Khairi Irina, Jamal Mohammad, Al-Sabah Suleiman, Ali Hamad, Dsouza Carol, Alshawaf Eman, Al-Ali Waleed, Al-Khaledi Ghanim, Al-Mulla Fahd, Abu-Farha Mohamed, Abubaker Jehad, Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity, Frontiers in Endocrinology, 12, 2021. Crossref
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Robinet Peggy, Ritchey Brian, Lorkowski Shuhui Wang, Alzayed Alexander M., DeGeorgia Sophia, Schodowski Eve, Traughber C. Alicia, Smith Jonathan D., Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function, Scientific Reports, 11, 1, 2021. Crossref
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Allavena Paola, Digifico Elisabeth, Belgiovine Cristina, Macrophages and cancer stem cells: a malevolent alliance, Molecular Medicine, 27, 1, 2021. Crossref
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Chen Yanke, Luan Jing, Jiang Ting, Cai Donghui, Sun Chao, Wang Xiaofei, Zhao Xiaoge, Gou Xingchun, Knockdown of EMMPRIN (OX47) in MRMT-1 Carcinoma Cells Inhibits Tumor Growth and Decreases Cancer-Induced Bone Destruction and Pain, Cancer Research and Treatment, 53, 2, 2021. Crossref
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Azizova G. I., Hasanova N. A., Dadashova A. R., DYNAMICS OF OSTEOACTIVIN IN PATIENTS WITH OSTEOPOROTIC FRACTURES , Bulletin of Problems Biology and Medicine, 1, 1, 2022. Crossref
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Abdelmagid Samir M., Sondag Gregory R., Moussa Fouad M., Belcher Joyce Y., Yu Bing, Stinnett Hilary, Novak Kimberly, Mbimba Thomas, Khol Matthew, Hankenson Kurt D., Malcuit Christopher, Safadi Fayez F., Mutation in Osteoactivin Promotes Receptor Activator of NFκB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function, Journal of Biological Chemistry, 290, 33, 2015. Crossref
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Bendell Johanna, Saleh Mansoor, Rose April A.N., Siegel Peter M., Hart Lowell, Sirpal Surendra, Jones Suzanne, Green Jennifer, Crowley Elizabeth, Simantov Ronit, Keler Tibor, Davis Thomas, Vahdat Linda, Phase I/II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Patients With Locally Advanced or Metastatic Breast Cancer, Journal of Clinical Oncology, 32, 32, 2014. Crossref