Publication de 6 numéros par an
ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502
Indexed in
Combinatorial Action of RUNX1 and PU.1 in the Regulation of Hematopoiesis
RÉSUMÉ
The hematopoietic stem cell (HSC) has the potential to differentiate into mature cells with distinct phenotypes and functions. As suggested in recent reports, this plasticity can expand to include nonhematopoietic lineages, and, indeed, the HSC may repopulate liver and muscle tissues, as well. Considering the flexibility in HSC differentiation, these processes are regulated by a relatively small number of factors, some of which are expressed in all lineages, whereas others are activated only in a specific cell type. Combined evidence from many studies suggests that alternative subsets of these factors work in a combinatorial manner to regulate specific promoters for the induction of a specific lineage. RUNX1 and PU.1 have a fundamental role in HSC differentiation in that multifactor complexes are assembled around these proteins leading to tissue-specific and synergistic gene activation. Here we describe the relationship of RUNX1 with PU.1 as a facet of the combinatorial relationships that determine hematopoietic lineage commitment.
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Kaur Gurpreet, Jalagadugula Gauthami, Mao Guangfen, Rao A. Koneti, RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency, Blood, 115, 15, 2010. Crossref
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Yang L., Jiang Y., Wu S.F., Zhou M.Y., Wu Y.L., Chen G.Q., CCAAT/enhancer-binding protein α antagonizes transcriptional activity of hypoxia-inducible factor 1 α with direct protein–protein interaction, Carcinogenesis, 29, 2, 2008. Crossref
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Bakshi Rachit, Hassan Mohammad Q., Pratap Jitesh, Lian Jane B., Montecino Martin A., van Wijnen Andre J., Stein Janet L., Imbalzano Anthony N., Stein Gary S., The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes, Journal of Cellular Physiology, 225, 2, 2010. Crossref
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Lever Elliott, Sheer Denise, The role of nuclear organization in cancer, The Journal of Pathology, 220, 2, 2010. Crossref
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Meng Guofeng, Mosig Axel, Vingron Martin, A computational evaluation of over-representation of regulatory motifs in the promoter regions of differentially expressed genes, BMC Bioinformatics, 11, 1, 2010. Crossref
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Sun Yaping, Sun John, Tomomi Toubai, Nieves Evelyn, Mathewson Nathan, Tamaki Hiroya, Evers Rebecca, Reddy Pavan, PU.1-Dependent Transcriptional Regulation of miR-142 Contributes to Its Hematopoietic Cell–Specific Expression and Modulation of IL-6, The Journal of Immunology, 190, 8, 2013. Crossref
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Li Donglan, Sinha Kislay K., Hay Maher A., Rinaldi Ciro R., Saunthararajah Yogen, Nucifora Giuseppina, RUNX1-RUNX1 Homodimerization Modulates RUNX1 Activity and Function, Journal of Biological Chemistry, 282, 18, 2007. Crossref
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Adorno-Cruz Valery, Kibria Golam, Liu Xia, Doherty Mary, Junk Damian J., Guan Dongyin, Hubert Chris, Venere Monica, Mulkearns-Hubert Erin, Sinyuk Maksim, Alvarado Alvaro, Caplan Arnold I., Rich Jeremy, Gerson Stanton L., Lathia Justin, Liu Huiping, Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance, Cancer Research, 75, 6, 2015. Crossref