Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 2.156 Facteur d'impact sur 5 ans: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2017019372
pages 211-217

Association of IL-6 -597 G/A Polymorphism with Cancer Risk: Evidence from a Meta-Analysis

Dingliang Qian
Department of Clinical Laboratory, Rui'an People's Hospital, Third Affiliated Hospital of Wenzhou Medical University, Rui'an 325200,China
Shaorong Yan
Department of Clinical Laboratory, Rui'an People's Hospital, Third Affiliated Hospital of Wenzhou Medical University, Rui'an 325200,China
Xiaowei Pan
Department of Clinical Laboratory, Rui'an Hospital of Traditional Chinese Medicine, Rui'an 325200, China

RÉSUMÉ

Although it has been suggested that the interleukin-6(IL-6) gene -597G/A polymorphism may be a risk factor for cancer, the conclusions from previous studies are inconsistent. To clarify the precise interrelation, we performed a comprehensive meta-analysis of 6 case-control studies involving 1,605 subjects (706 cases and 899 controls). The overall results showed no significant association between the IL6 -597G/A polymorphism and cancer risk in the overall population (CC vs GG: OR = 2.38, 95% CI = 0.62–9.14; CG vs GG: OR = 1.23, 95% CI = 0.66–2.27; dominant model: OR = 1.32, 95% CI = 0.63–2.79; recessive model: OR = 1.93, 95% CI = 0.72–v5.17). Subgroup analysis by ethnicity and cancer type yielded the same result. Therefore, the current evidence from this meta-analysis did not support the hypothesis of IL-6 -597G/A polymorphism as a risk factor of cancer. Conclusive evidence on the effects of this variant in cancer should be addressed in future studies.


Articles with similar content:

Association of ERCC1 Polymorphisms with the Risk of Colorectal Cancer: A Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 3
Jiansong Jiang, Jianfeng Chen, Ningjie Sun, Gaojian Luo, Xiansheng Chen, Gang Hu, Haiming Wu
Association between 12p13 Polymorphisms and Ischemic Stroke in Asian Populations: New Evidence from a Case-Control Study and a Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 4
Xu Liu, Ruixia Zhu, Tongling Xiao, Zhiyi He
TCF7L2 rs12255372 (G > T) Polymorphism Contributes to Breast Carcinogenesis: Evidence from a Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 4
Qun Zhang, Zexing Wang, Weiwei Nie, Fengxia Chen, Bin Yang, Yanru Wang, Xiaoxiang Guan
Association between ABCB1 G2677T/A Polymorphism and Breast Cancer Risk: A Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.29, 2019, issue 3
Kangke Shi, Zhihao Wei, Hongchao Liu, Yu Zhang
ABCB1 Polymorphisms and Childhood Acute Lymphoblastic Leukemia Risk: A Meta-Analysis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 2
Lu Zhan, Junlan Lian, Zhengyang Shao, Sunyao Wang, Haili Jin, Jiajun Ding