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Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 2.156 Facteur d'impact sur 5 ans: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2017019380
pages 205-210

Modeling Mesenchymal Stem Cells in TMJ Rheumatoid Arthritis and Osteoarthritis Therapy

Nedime Serakinci
Near East University, Faculty of Medicine, Department of Medical Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus; Near East University, Faculty of Arts and Sciences, Dept. of Molecular Biology and Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus
Gokce Savtekin
Near East University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Nicosia, Turkish Republic of North Cyprus

RÉSUMÉ

Stem cells have self-renewal capacity and an ability to differentiate into particular cell types generating mature cells. Mesenchymal stem cells (MSCs) have a significant role in tissue homeostasis, which leads into tissue regeneration. MSCs are rare pluripotent cells supporting hematopoietic and mesenchymal cell lineages. MSCs are also believed to have therapeutic power over temporomandibular joint (TMJ) disorders (TMDs). The most common type of TMD is articular disc displacement, which induces progressive degenerative changes. These changes lead to rheumatoid arthritis or osteoarthritis. In this review, use of human mesenchymal cells (hMSCs) for therapeutic treatment of inflammatory diseases of TMJ is discussed.


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