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Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 2.156 Facteur d'impact sur 5 ans: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2018024760
pages 1-15

Epigenetic Modification Related to Acetylation of Histone and Methylation of DNA as a Key Player in Immunological Disorders

Muhammad Imran Qadir
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan
Farha Anwer
Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan


Epigenetics is the variation in organisms that occur by changes in gene expression, and it also occurs in the genetic code. The immune system diseases arise from primarily epigenetic changes of obscure etiology. The current studies demonstrate that a portion of the rearrangements are created by the association of epigenetic alterations. For example, acetylation of histones and methylation of DNA are accounted for. These adjustments in DNA likewise showed the impact in mouse models and immune system illnesses in human. Through this review, it could be reasoned that epigenetic tweaks might be a novel restorative approach against these maladies.

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