Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 1.841 Facteur d'impact sur 5 ans: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v20.i2.70
pages 171-180

Circulating Osteogenic Precursor Cells

Robert Pignolo
Departments of Medicine and Orthopaedic Surgery, University of Pennsylvania, School of Medicine
Eileen M. Shore
Departments Orthopaedic Surgery, and Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania

RÉSUMÉ

Circulating osteogenic precursor (COP) cells are blood-borne cells that express a variety of osteoblastic markers and are able to form bone in vivo. Strong evidence suggests that COP cells are derived from bone marrow and are of hematopoietic origin. The study of COP cells has been limited by several factors, including the difficulty in establishing long-term cultures and lack of a standardized protocol for their isolation and identification. However, experimental evidence supports that COP cells seed sites of injury and inflammation in response to homing signals and are involved in processes of pubertal growth, fracture, and diverse conditions of heterotopic bone formation. The role of COP cells in physiologic and pathophysiologic conditions of de novo bone formation suggests that they may serve as future targets for diagnostic measurements and therapeutic interventions.


Articles with similar content:

Osteopoiesis: The Early Development of Bone Cells
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 3&4
Michael W. Long, Sujata Kale
Control of Osteoclast Differentiation
Critical Reviews™ in Eukaryotic Gene Expression, Vol.8, 1998, issue 1
G. David Roodman, Sakamuri V. Reddy
Regulation of Chemokine Expression in the Tumor Microenvironment
Critical Reviews™ in Immunology, Vol.34, 2014, issue 2
Anton V. Gorbachev, Robert L. Fairchild
The Pathophysiological Role of Chemokines in the Regulation of NK Cell Tissue Homing
Critical Reviews™ in Oncogenesis, Vol.19, 2014, issue 1-2
Giovanni Bernardini, Angela Santoni
Molecular Aspects of Cardiac Differentiation in Embryonic Stem Cells
Critical Reviews™ in Biomedical Engineering, Vol.37, 2009, issue 4-5
Balaji M. Rao, Prasenjit Sarkar