Publication de 6 numéros par an
ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502
Indexed in
An Integrated Biological Approach to Nuclear Receptor Signaling in Physiological Control and Disease
RÉSUMÉ
The nuclear receptors (NRs)vitamin D receptor (VDR); peroxisome proliferator-activated receptor (PPAR) α, δ, γ; and pregnane X receptor (PXR)act as sensors for various molecules encountered by the body on a daily basis. The effects of these ligands can be understood by the fact that numerous genes involved in the cellular processes, such as general homeostasis, growth, and defense against microbes, are under the control of these five NRs. The target gene and protein expression patterns of VDR, PPARs, and PXR; the resulting changes in metabolite levels; and their physiological consequences create a network that can be monitored by high-throughput methods and analyzed by multimodal approaches, such as systems biology. We suggest that the fine regulation of this NR network is specific to each human individual and depends, in part, on the constellation of regulatory small nucleotide polymorphisms (SNPs) in his or her genome. When regulatory SNPs affect NRs response elements, lifetime exposure to food components will have different accumulative consequences on the expression of the respective NR target genes. These differences will influence the individual's susceptibility to aging-related diseases, such as type 2 diabetes, atherosclerosis, cancer, and osteoporosis. Furthermore, it is anticipated that systems biology methods will also help to identify the most critical genes, proteins, or metabolites in the NR network that will serve as biomarkers for the early detection of these diseases.
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Ramaseshadri Parthasarathy, Farkaš Robert, Palli Subba Reddy, Recent Progress in Juvenile Hormone Analogs (JHA) Research, in Insect Growth Disruptors, 43, 2012. Crossref
-
Norman Anthony W., 1α,25(OH)2 Vitamin D3Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses, in Principles of Bone Biology, 2008. Crossref
-
Adorini Luciano, Amuchastegui Susana, Corsiero Elisa, Laverny Gilles, Le Meur Thomas, Penna Giuseppe, Vitamin D receptor agonists as anti-inflammatory agents, Expert Review of Clinical Immunology, 3, 4, 2007. Crossref
-
Studenski Stephanie, Ferrucci Luigi, Resnick Neil M., Geriatrics, in Clinical and Translational Science, 2009. Crossref
-
Singh Prashant, Campbell Moray, Vitamin D Receptor, in Vitamin D, 20124841, 2012. Crossref
-
Singh Prashant K, Long Mark D, Battaglia Sebastiano, Hu Qiang, Liu Song, Sucheston-Campbell Lara E, Campbell Moray J, VDR regulation of microRNA differs across prostate cell models suggesting extremely flexible control of transcription, Epigenetics, 10, 1, 2015. Crossref
-
Rokutanda Nana, Iwasaki Toshiharu, Odawara Hiroki, Nagaoka Rin, Miyazaki Wataru, Takeshita Akira, Koibuchi Yukio, Horiguchi Jun, Shimokawa Noriaki, Iino Yuichi, Morishita Yasuo, Koibuchi Noriyuki, Augmentation of estrogen receptor-mediated transcription by steroid and xenobiotic receptor, Endocrine, 33, 3, 2008. Crossref
-
Campbell Moray J., Carlberg Carsten, Koeffler H. Phillip, A Role for the PPARγin Cancer Therapy, PPAR Research, 2008, 2008. Crossref
-
Abedin S. Asad, Thorne James L., Battaglia Sebastiano, Maguire Orla, Hornung Laura B., Doherty Alan P., Mills Ian G., Campbell Moray J., Elevated NCOR1 disrupts a network of dietary-sensing nuclear receptors in bladder cancer cells, Carcinogenesis, 30, 3, 2009. Crossref
-
Westerhoff Hans V., Kolodkin Alexey, Conradie Riaan, Wilkinson Stephen J., Bruggeman Frank J., Krab Klaas, van Schuppen Jan H., Hardin Hanna, Bakker Barbara M., Moné Martijn J., Rybakova Katja N., Eijken Marco, van Leeuwen Hans J. P., Snoep Jacky L., Systems biology towards life in silico: mathematics of the control of living cells, Journal of Mathematical Biology, 58, 1-2, 2009. Crossref
-
Matsuda Satoru, Kitagishi Yasuko, Peroxisome Proliferator-Activated Receptor and Vitamin D Receptor Signaling Pathways in Cancer Cells, Cancers, 5, 4, 2013. Crossref
-
Bouffard Nicole A., Cutroneo Kenneth R., Badger Gary J., White Sheryl L., Buttolph Thomas R., Ehrlich H. Paul, Stevens-Tuttle Debbie, Langevin Helene M., Tissue stretch decreases soluble TGF-β1 and type-1 procollagen in mouse subcutaneous connective tissue: Evidence from ex vivo and in vivo models, Journal of Cellular Physiology, 214, 2, 2008. Crossref
-
Kolodkin Alexey N, Bruggeman Frank J, Plant Nick, Moné Martijn J, Bakker Barbara M, Campbell Moray J, van Leeuwen Johannes P T M, Carlberg Carsten, Snoep Jacky L, Westerhoff Hans V, Design principles of nuclear receptor signaling: how complex networking improves signal transduction, Molecular Systems Biology, 6, 1, 2010. Crossref
-
Kolodkin Alexey, Boogerd Fred C., Plant Nick, Bruggeman Frank J., Goncharuk Valeri, Lunshof Jeantine, Moreno-Sanchez Rafael, Yilmaz Nilgun, Bakker Barbara M., Snoep Jacky L., Balling Rudi, Westerhoff Hans V., Emergence of the silicon human and network targeting drugs, European Journal of Pharmaceutical Sciences, 46, 4, 2012. Crossref
-
Carlberg Carsten, Molecular Approaches for Optimizing Vitamin D Supplementation, in Vitamin D Hormone, 100, 2016. Crossref
-
Beaumont Javier, Arias Teresa, López Begoña, González Arantxa, Ravassa Susana, Hermida Nerea, Querejeta Ramón, Díez Javier, Avances en cardiopatía hipertensiva. Mecanismos de remodelado implicados en la transición de la hipertrofia a la insuficiencia cardiaca, Revista Española de Cardiología Suplementos, 7, 6, 2007. Crossref
-
Bajwa Amandeep, Forster Megan N., Maiti Aparna, Woolbright Benjamin L., Beckman Matthew J., Specific regulation of CYP27B1 and VDR in proximal versus distal renal cells, Archives of Biochemistry and Biophysics, 477, 1, 2008. Crossref
-
Pereira Fábio, Larriba María Jesús, Muñoz Alberto, Vitamin D and colon cancer, Endocrine-Related Cancer, 19, 3, 2012. Crossref
-
Howd Robert A., Fan Anna M., Use of Cancer Risk Assessments in Determination of Regulatory Standards, in Cancer Risk Assessment, 2010. Crossref
-
Chung Jae Heun, Seo Arnold Y., Chung Sang Woon, Kim Mi Kyung, Leeuwenburgh Christiaan, Yu Byung Pal, Chung Hae Young, Molecular mechanism of PPAR in the regulation of age-related inflammation, Ageing Research Reviews, 7, 2, 2008. Crossref
-
Neme Antonio, Nurminen Veijo, Seuter Sabine, Carlberg Carsten, The vitamin D-dependent transcriptome of human monocytes, The Journal of Steroid Biochemistry and Molecular Biology, 164, 2016. Crossref
-
Studenski Stephanie, Ferrucci Luigi, Research in Special Populations, in Clinical and Translational Science, 2017. Crossref
-
Martin Matthew T., Brennan Richard J., Hu Wenyue, Ayanoglu Eser, Lau Christopher, Ren Hongzu, Wood Carmen R., Corton J. Christopher, Kavlock Robert J., Dix David J., Toxicogenomic Study of Triazole Fungicides and Perfluoroalkyl Acids in Rat Livers Predicts Toxicity and Categorizes Chemicals Based on Mechanisms of Toxicity, Toxicological Sciences, 97, 2, 2007. Crossref
-
Pyper Sean R., Viswakarma Navin, Yu Songtao, Reddy Janardan K., PPARα: Energy Combustion, Hypolipidemia, Inflammation and Cancer, Nuclear Receptor Signaling, 8, 1, 2010. Crossref
-
Werner Thomas, Regulatory networks: Linking microarray data to systems biology, Mechanisms of Ageing and Development, 128, 1, 2007. Crossref
-
Karlsen T. H., Boberg K. M., Schrumpf E., Role of polymorphisms in genes involved in bile acid detoxification pathways in primary sclerosing cholangitis, in Bile Acids: Biological Actions and Clinical Relevance, 155, 2007. Crossref
-
Klaassen Curtis, Lu Hong, Xenobiotic Receptors CAR and PXR, in Nuclear Receptors, 2010. Crossref
-
Maguire Orla, Campbell Moray J., The Vitamin D Receptor (NR1I1), in Nuclear Receptors, 2010. Crossref
-
Wortham Matthew, Czerwinski Maciej, He Lin, Parkinson Andrew, Wan Yu-Jui Yvonne, Expression of Constitutive Androstane Receptor, Hepatic Nuclear Factor 4α, and P450 Oxidoreductase Genes Determines Interindividual Variability in Basal Expression and Activity of a Broad Scope of Xenobiotic Metabolism Genes in the Human Liver, Drug Metabolism and Disposition, 35, 9, 2007. Crossref
-
Lonard David M., Lanz Rainer B., O’Malley Bert W., Nuclear Receptor Coregulators and Human Disease, Endocrine Reviews, 28, 5, 2007. Crossref
-
Yadav Upendra, Kumar Pradeep, Rai Vandana, Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis, Egyptian Journal of Medical Human Genetics, 21, 1, 2020. Crossref
-
Zhao Xiansi, Patton Jeffrey R., Ghosh Sajal K., Fischel-Ghodsian Nathan, Shen Ling, Spanjaard Remco A., Pus3p- and Pus1p-Dependent Pseudouridylation of Steroid Receptor RNA Activator Controls a Functional Switch that Regulates Nuclear Receptor Signaling, Molecular Endocrinology, 21, 3, 2007. Crossref
-
Degenhardt Tatjana, Matilainen Merja, Herzig Karl-Heinz, Dunlop Thomas W., Carlberg Carsten, The Insulin-like Growth Factor-binding Protein 1 Gene Is a Primary Target of Peroxisome Proliferator-activated Receptors, Journal of Biological Chemistry, 281, 51, 2006. Crossref
-
Sánchez-Jiménez F., Montañez R., Correa-Fiz F., Chaves P., Rodríguez-Caso C., Urdiales J.L., Aldana J.F., Medina M.A., The usefulness of post-genomics tools for characterization of the amine cross-talk in mammalian cells, Biochemical Society Transactions, 35, 2, 2007. Crossref
-
Navas-Delgado Ismael, Montañez Raúl, Pino-Ángeles Almudena, Moya-García Aurelio A, Urdiales José Luis, Sánchez-Jiménez Francisca, Aldana-Montes José F, AMMO-Prot: amine system project 3D-model finder, BMC Bioinformatics, 9, S4, 2008. Crossref
-
Carlberg Carsten, Haq Afrozul, The concept of the personal vitamin D response index, The Journal of Steroid Biochemistry and Molecular Biology, 175, 2018. Crossref
-
Thorne James, Campbell Moray J., The Molecular Cancer Biology of the VDR, in Vitamin D and Cancer, 2011. Crossref
-
Warwick Timothy, Schulz Marcel H, Gilsbach Ralf, Brandes Ralf P, Seuter Sabine, Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor, Nucleic Acids Research, 50, 7, 2022. Crossref
-
Kolodkin Alexey N., Boogerd Fred C., Bruggeman Frank J., Westerhoff Hans V., Modeling Approaches in Systems Biology, Including Silicon Cell Models, in Systems Biology and Livestock Science, 2011. Crossref
-
Alsufiani Hadeil M., AlGhamdi Shareefa A., AlShaibi Huda F., Khoja Sawsan O., Saif Safa F., Carlberg Carsten, A Single Vitamin D3 Bolus Supplementation Improves Vitamin D Status and Reduces Proinflammatory Cytokines in Healthy Females, Nutrients, 14, 19, 2022. Crossref
-
Westerhoff Hans V., Verma Malkhey, Bruggeman Frank J., Kolodkin Alexey, Swat Maciej, Hayes Neil, Nardelli Maria, Bakker Barbara M., Snoep Jacky L., From Silicon Cell to Silicon Human, in BetaSys, 2011. Crossref
-
Hussain Shahid, Yates Clayton, Campbell Moray J., Vitamin D and Systems Biology, Nutrients, 14, 24, 2022. Crossref