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Critical Reviews™ in Eukaryotic Gene Expression
Facteur d'impact: 1.734 Facteur d'impact sur 5 ans: 1.848 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2015013572
pages 163-174

Bacteria-Containing Vacuoles: Subversion of Cellular Membrane Traffic and Autophagy

Bor Luen Tang
Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, Singapore, and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore


Intracellular bacterial pathogens drive the formation of host membrane-derived pseudo-organelles that facilitate their replication, survival, or dormancy. The formation and maintenance of these bacteria-containing vacuoles (BCVs) are dependent on the bacteria's ability to usurp the host's intracellular membrane system, in particular dynamic compartments involved in exo-/endocytic membrane traffic and autophagy. Bacteria are typically internalized by phagocytosis, and the compartment matures through endosomal fusion. The bacteria-containing phagosome/endosome often becomes the base for BCV formation. Diverse strategies used by different bacterial pathogens prevent the BCV from being destroyed via the endolysosomal pathway. Furthermore, bacterial survival or proliferation in BCVs could be augmented by host membrane transport processes subverted by secreted bacterial factors, which facilitate the acquisition of membrane sources and nutrients. BCVs may be targeted for destruction by autophagy, and various facultative and obligate intracellular bacteria have evolved ways to evade or even exploit autophagy. Here we review examples of bacterial subversion of host cellular membrane transport and autophagy machinery for a productive invasion.

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