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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v5.i1.80
pages 73-82

Prophylactic Effect of Probiotic Strains Bifidobacterium Animalis VKL and VKB on Stress-Induced Lesions in the Gastric Mucosa of Rats

Mykola Ya. Spivak
Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, Kyiv
L. M. Lazarenko
Kyiv Taras Shevchenko National University, Kyiv, Ukraine
Tetyana M. Falalyeyeva
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
O. V. Virchenko
Zabolotnyi Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
K. S. Neporada
Ukrainian Medical Stomatological Academy, Poltava, Ukraine


The effect of probiotic strains Bifidobacterium animalis VKL and VKB and their mixture on erosive and ulcerative lesions in the rat gastric mucosa (GM) induced by water immersion restraint stress was studied. It has been found that separate prophylactic introduction of either Bifidobacterium animalis VKL or Bifidobacterium animalis VKB for 14 days does not affect the stress-induced GM erosive and ulcerative lesions. However, prophylactic introduction of Bifidobacterium animalis VKL and VKB mixture is effective in protecting the GM from the damage. One of the gastroprotective mechanisms by these probiotic strains is prevention of mucus barrier from degradation, which is manifested as a decrease in free fucose and hexuronic acids content in the GM. The results obtained are the experimental confirmation of the expediency of the probiotics to prevent stress-induced lesions in the GM.

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