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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v5.i1.30
pages 33-39

Protective Effect of Melatonin in Experimental Glaucoma in Rats

Irina N. Mikheytseva
Filatov State Institute of Eye Diseases and Tissue Therapy, National Academy of Medical Sciences of Ukraine, Odessa, Ukraine


The effect of melatonin on the level of amino acid neurotransmitters of the retina in rat glaucoma neuropathy was studied. Glaucoma was caused by prolonged systemic administration of adrenaline. An experiment involved three groups of rats: intact animals, those with the model of glaucoma, and the rats with the model of glaucoma treated with melatonin. Melatonin was injected to rats with developed glaucoma during 1 month at a dose of 0.1 mg / kg. In the vitreous body (corpus vitreum), as a site of retinal neurotransmitter accumulation, the content of free amino acids was determined by ion-exchange chromatography. It has been revealed that chronic adrenalin-induced glaucoma neuropathy results in a change in the retinal neurotransmitter profile, namely, the content of glutamate and aspartate, excitatory amino acids, increases, while the level of GABA and glycine, inhibitory amino acids, decreases, leading to increased excitation index by 55%. The imbalance of amino acid neurotransmitters was largely normalized by prolonged administration of melatonin. A decrease under the influence of the latter in the content of excitatory amino acids and an increase in the level of inhibitory ones resulted in a decrease in excitation index by 27% compared to the untreated group. Thus, melatonin-induced reduction of excitatory impulses in the retina may determine its neuroprotective activity in glaucoma neuropathy.

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