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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v5.i1.60
pages 57-63

Electrical Properties of Retinal Ganglion Cells of the Rats with Streptozotocin-Induced Diabetes Mellitus

Kyryl I. Kuznetsov
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Nataliya N. Veselovskaya
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Vitally Y. Maslov
Bogomolets Institute of Physiology, NASU, Kyiv, Ukraine
Svetlana A. Fedulova
O. O. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Mycola S. Veselovsky
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

RÉSUMÉ

On isolated retinal preparation from rats with streptozotocin-induced diabetes mellitus in whole-cell configuration, basic electrical properties of retinal ganglion cells (RGC) were studied. It has been shown that on the 8th week after streptozotocin injection, maximal depolarization-induced firing frequency is reduced and decay time constant of high-frequency stimulation-induced calcium signals increases, compared with the values in control animals. The data obtained point at functional changes in RGC of streptozotocin-induced diabetic rats, and possible mechanisms of such changes are discussed.


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