Abonnement à la biblothèque: Guest
International Journal of Physiology and Pathophysiology

Publication de 4  numéros par an

ISSN Imprimer: 2155-014X

ISSN En ligne: 2155-0158

SJR: 0.116

Activation of Endogenous Hydrogen Sulfide Synthesis Inhibits Mitochondrial Permeability Transition Pore Opening and Restores Constitutive NO-Synthase Coupling in Old Rat Heart

Volume 9, Numéro 1, 2018, pp. 59-67
DOI: 10.1615/IntJPhysPathophys.v9.i1.70
Get accessGet access

RÉSUMÉ

We studied effects of pyridoxal-5-phosphate (P5P), as a cofactor for H2S synthesizing enzyme, on the sensitivity of mitochondrial permeability transition pore (MPTP) opening to Ca,2+ its natural inducer, in old rat heart, as well as H2S content, oxidative and nitrosative stress indicators in the heart mitochondria. It has been shown that in old rats oxidative and nitrosative stress develop, which is accompanied by a decrease in the constitutive Ca2+ -dependent NO-synthase (cNOS) coupling index. P5P application inhibits Ca2+ -induced MPTP opening by reducing the sensitivity to the inductor in old rat heart. Applying a modulator of H2S synthesis results in an increase in hydrogen sulfide content 4.2 times and promotes a decrease in O2- generation speed 3.5 times in comparison with these indicators in old animals. An important consequence of stimulating hydrogen sulfide endogenous synthesis in aging is the increase in cNOS activity 1.9 times and a decrease in the activity of Ca2+ -independent inducible NO-synthase (iNOS) 4.3 times in the heart mitochondria. Under these conditions, cNOS coupling index in organelles increases 8.7 times, relative to the values in old animals. Thus, H2S acts as a regulator of MPTP opening and NO content, by increasing cNOS activity and restituting the enzyme coupled state, which indicates the role of this gaseous transmitter in cardiovascular pathology.

CITÉ PAR
  1. Pavlovskiy Yaroslav, Yashchenko Antonina, Zayachkivska Oksana, H2S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury via CBS, CSE, and TST Expression, Frontiers in Pharmacology, 11, 2020. Crossref

  2. Yavtushenko Ivan V., Nazarenko Svitlana M., Katrushov Oleksandr V., Kostenko Vitalii O., QUERCETIN LIMITS THE PROGRESSION OF OXIDATIVE AND NITROSATIVE STRESS IN THE RATS’ TISSUES AFTER EXPERIMENTAL TRAUMATIC BRAIN INJURY, Wiadomości Lekarskie, 73, 10, 2020. Crossref

  3. Kozaeva Rita, Klymenko Mykola O., Katrushov Oleksandr V., Kostenko Vitalii O., BIOFLAVONOIDS AS AGENTS FOR CORRECTING NITRO-OXIDATIVE STRESS AND SALIVARY GLAND FUNCTIONS IN RATS EXPOSED TO ALCOHOL DURING MODELED LIPOPOLYSACCHARIDE-INDUCED SYSTEMIC INFLAMMATORY RESPONSE, Wiadomości Lekarskie, 75, 3, 2022. Crossref

1032 Vues d'articles 6 Téléchargements d'articles Métrique
1032 VUES 6 TÉLÉCHARGEMENTS 3 Crossref CITATIONS Google
Scholar
CITATIONS

Articles avec un contenu similaire:

Age-Associated Mitochondrial Dysfunction in the Heart Accompanied by Constitutive NO-Synthases Uncoupling on the Background of Oxidative and Nitrosative Stress International Journal of Physiology and Pathophysiology, Vol.8, 2017, issue 2
Nataliya A. Strutynska, Lidiya A. Mys, Alina Yu. Budko, Vadim F. Sagach, Anatoliy V. Kotsuruba
Hydrogen Sulfide Inhibits Calcium-Induced Mitochondrial Permeability Transition Pore Opening in the Heart of Spontaneously Hypertensive Rats International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 4
Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Nataliya A. Dorofeyeva
The Effect of Lomg-Term Exercise Training on the Changes in the Functional State of Heart duringIschemia-Reperfusion, the Sensitivity of Calcium- Induced Mitochondrial Permeability Transition Pore and the Uncoupling Protein 3 Expression International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 3
Snizhana V. Chorna, Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, N. M. Gaidai, Sergiy O. Talanov
Inhibition of Mitochondrial Hydrogen Sulfide Production Worsens Heart Contractility and Enhances Sensitivity of Mitochondrial Permeability Transition Pore to Calcium International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 2
Nataliya A. Strutynska, Alina Yu. Luchkova, Vadim F. Sagach, Yuliya V. Hoshovs'ka, Raisa A. Fedichkina
Hydrogen Sulfide Inhibits Calcium-Induced Mitohondrial Permeability Transition Pore Opening in the Heart of Adult and Old Rats International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 2
Snizhana V. Chorna, Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Olena M. Semenykhina

Dernier numéro

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain