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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i1.30
pages 17-26

Effect of Germanium Citrate on Immunophysiological Activity of the Rats' Organism

Rostyslav S. Fedoruk
Institute of animal biology, National Academy of Agricultural Sciences of Ukraine, Lviv, Ukraine
Maryana I. Khrabko
Institute of animal biology, National Academy of Agricultural Sciences of Ukraine, Lviv, Ukraine
Olga P. Dolaychuk
Institute of animal biology, National Academy of Agricultural Sciences of Ukraine, Lviv, Ukraine

RÉSUMÉ

The effects of various doses of gemanium citrate on immunophysiological mechanisms of homeostatic reactions in rats of different age and physiological conditions were studied. It has been revealed that daily exposure of female rats and their offspring to germanium citrate, obtained by nanotechnology (groups II–IV) and chemical synthesis (groups V–VI), in doses of 10, 20, 200, and 2000 μg/kg results in immunophysiological changes in the organism of animals in all research groups. In the blood of female rats after 4 months of treating with germanium, and in the blood of their offspring (V and VI groups) on the 60–65th day of life, the content of immunoglobulins increases 1.73–2.45 times (females) and 1.05–1.1 times (males); the content of circulating immune complexes increased 1.12–3.10 and 1.27–2.02 times; the content of sialic acids increased 1.01–1.54 and 1.39–1.58 times; and the content of protein-bound hexoses increased 1.12–1.17 and 1.20–1.33 times, respectively. In all rats, the content of medium-weight molecules is reduced by 6–17%, the platelet count decreased in females and males by 22–39% and 6–23%, respectively, as well as phagocytic activity decreased by 5.3–10.2% and 4.4–5.7%, respectively, indicating the same direction of immunobiological action of citrate germanium in adults and young rats of different sexes. The concentration of ceruloplasmin and the number of leukocytes decreased in females of groups III–VI and grew in males of groups II–VI. Based on the analysis of the immune system indicators and the content of glycoproteins in the blood, we have assessed the immunophysiological features of the effects of low and high doses of germanium citrate depending on the duration of its intake and systemic communication of mother and fetus. The obtained results testify to gender and agedependent features of hepato-immunological communication of these animals under prolonged treating with germanium citrate. Biological effect of the latter is more pronounced in rats receiving it in doses of 20 and 200 μg/kg.


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