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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v8.i1.50
pages 45-55

Body's Response to Dosed Hypoxic Hypoxia in Healthy Subjects and Patients with Pre-Diabetic Disorders of Hydrogen Metabolism

Oleg V. Korkushko
Chebotarev Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Valeriy B. Shatilo
Chebotarev Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
V. P. Chyzhova
Chebotarev Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
S. S. Naskalova
Chebotarev Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
Ye. D. Osmak
Chebotarev Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
A. V. Gremiakov
Chebotarev Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
I. A. Antoniuk-Scheglova
Chebotarev Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
G. V. Gavalko
Chebotarev Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
N. S. Naumchuk
Chebotarev Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

RÉSUMÉ

The aim of the study was to find out the features of body's response to acute hypoxic test in patients with pre-diabetic disorders of carbohydrate metabolism. The study involved 22 healthy subjects and 18 patients with pre-diabetic disorders of hydrogen metabolism, aged 50 to 74 years. Each of them underwent dosed hypoxic test (breathing gas mixture containing 12% oxygen for up to 20 minutes) with monitoring of blood saturation (SpO2), respiratory rate, blood pressure, heart rate, and a standard glucose tolerance test (GTT) to check the concentration of blood plasma glucose and insulin. The patients with pre-diabetic hydrogen metabolism disturbances revealed a significant decrease in SpO2 and less effective functioning of the respiratory and the cardiovascular systems compared with the healthy subjects without impaired hydrogen metabolism. After redistribution of examined subjects into a subgroup with satisfactory resistance to hypoxia (subgroup 1, SpO2 more than 80%) and with low resistance to hypoxia (subgroup 2, SpO2 80% or less) depending on the degree of hypoxia-induced SpO2 decrease, we have found that the fasting glucose level after 2-hour GTT was significantly higher in a subgroup 2 compared to a subgroup 1. The results obtained indicate the relationship of the body's response to hypoxia, including the degree of arterial hypoxemia in acute hypoxic test and the level of fasting glucose at a standard GTT. The patients with pre-diabetic disturbances of carbohydrate metabolism are characterized with lower resistance to hypoxic hypoxia.