Abonnement à la biblothèque: Guest
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections
International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v6.i1.10
pages 1-11

Role of HIF-1 in Neuronal Mechanisms of Adaptation to Psychoemotional and Hypoxic Stress

Elena A. Rybnikova
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Ksenia A. Baranova
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Tatjana S. Gluschenko
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Oleg Vetrovoy
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Maria Sidorova
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Volodymyr I. Portnichenko
International Center for Astronomical, Medical and Ecological Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine; Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

RÉSUMÉ

Using quantitative immunohistochemistry, neuronal expression of α-subunit of the transcriptional factor HIF-1 was studied in the hippocampus and the neocortex of rats in response to pathogenic psychoemotional stress (model of posttraumatic stress disorder, PTSD) and hypoxic stress (severe hypobaric hypoxia, 180 mm Hg, 3 h), as well as following neuroprotective hypoxic pre- and postconditioning. Prolonged overexpression of HIF-1 α in the hippocampus and the neocortex of rats in response to the psychoemotional stress in PTSD paradigm, but not hypoxic stress, has been observed. Hypoxic pre- and postconditioning with mild hypobaric hypoxia (360 Torr, 2 h, 3 trials spaced at 24 h), which promotes adaptation to the psychoemotional stress, was shown to abolish the prolonged HIF-1 α overexpression. In addition, hypoxic postconditioning up-regulated HIF-1α expression in the brain neurons of rats survived severe hypoxia by improving the structure and functional rehabilitation after severe hypoxic stress. The results obtained indicate that a transcription factor HIF-1 is particularly involved in the processes of adaptation/maladaptation to the action of injurious stresses, but its role depends upon the nature of a stressor.


Articles with similar content:

Dependence of the Endocrine Function of Ischemic Ovarian Tissue Transplant on the Lipid Peroxidation Intensity
International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 1
Yuliya O. Bozhkova, Iryna A. Trutaieva, Ahmed A. Gawas, Victoria V. Kiroshka
Pathological Remodeling of Myocardium in Spontaneous Hypertensive Rats with Experimental Diabetes Mellitus: Role of Mitochondrial Dysfunction
International Journal of Physiology and Pathophysiology, Vol.6, 2015, issue 2
Andriy V. Abramov, Yuriy M. Kolesnyk, Myhaylo Y. Kolesnyk
Dynamics of Regeneration of Striated Muscles in Rats with Posttraumatic Reflex Contractures
International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 3
Victoria V. Pankevych, Svetlana V. Ushtan, Ulyana D. Matolych
Changes in the Brain Testosterone Metabolism and Sexual Behavior of Male Rats Prenatally Exposed to Methyldopa and Stress
International Journal of Physiology and Pathophysiology, Vol.7, 2016, issue 3
Nadiya D. Nosenko, Anna A. Limareva, Larisa V. Tarasenko, Alexander G. Reznikov
Nutrition and Diabetes Mellitus: How are They Interlinked?
Critical Reviews™ in Eukaryotic Gene Expression, Vol.26, 2016, issue 4
Muhammad Sajid Hamid Akash, Kanwal Rehman