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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v7.i3.70
pages 247-253

The Ways of Lipid Peroxidation and Protein Activation in Chronic Kidney Disease

Lesya V. Korol
Institute of Nephrology, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine

RÉSUMÉ

We studied spontaneous and metal-induced oxidation of lipids and proteins in in vitro modeling of the pathways of lipid peroxidation from the formation of malondialdehyde (MDA) and protein carbonyl groups (PCG) in 86 patients with chronic pyelonephritis (CPN) and 64 patients suffering from chronic glomerulonephritis (CGN) without disturbing the excretory function of the kidneys. It has been found that the MDA content in the blood serum of patients with CPN and CGN increases 2 and 2.3 times, respectively, compared to that in a group of practically healthy individuals. In erythrocytes of CPN and CGN, MDA content grows by 14%, and 29%, respectively; PCG content increases 1.5 and 2 times. Patients with CGN demonstrate more pronounced increase in both MDA and PCG content in the blood. Stimulation in vitro of lipid peroxidation processes contributes much to the growth of these indicators compared to the baseline prior to stimulation. When modeling in vitro ascorbate- and NADPH-dependent pathways of lipid and protein peroxidation, an increase in MDA and PCG production in both groups of patients, especially in the second pathway, are observed, which should be taken into account in the correction of oxidative processes and antioxidant treatment.


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