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International Journal of Physiology and Pathophysiology

Publication de 4  numéros par an

ISSN Imprimer: 2155-014X

ISSN En ligne: 2155-0158

SJR: 0.116

Contribution of Serotonin to Regulation of Tissue Respiration and Bile Secretory Function of the Liver

Volume 7, Numéro 2, 2016, pp. 137-147
DOI: 10.1615/IntJPhysPathophys.v7.i2.50
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RÉSUMÉ

In acute experiments on laboratory male rats, we have shown that intraportal administration of serotonin (5-HT, 10 µg / kg) evokes an increase in the liver oxygen consumption by 28.8% (P < 0.001) and a decrease in oxygen tension by 19.3% (P < 0.001). The effects of 5-HT on tissue respiration in the liver are realized through 5-HT2 receptors, because their preliminary blockade by ketanserin (3 mg / kg) results in both preventing the effects of exogenous 5-HT and inhibiting the action of endogenous autacoid. Serotonin reduces the amount of secreted bile by 13.5% (P < 0.05); it increases the concentration of conjugated bile acids, and decreases the content of free cholates, indicating their enhanced conjugation with taurine and glycine in the liver cells. However, this biogenic amine does not stimulate the synthesis of primary bile acids. An introduction of the latter against the background of 5-HT2 receptor blockade by ketanserin also results in a decrease in the rate of bile secretion, but in this case stimulatory effect of the autacoid on bile acid conjugation with taurine and glycine is not manifested, and the content of free cholates is not reduced.

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