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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v6.i3.80
pages 249-259

Changes in Processes of Free Radical Oxidation of Lipids and Proteins, Antioxidant Defense in Rats with Thyroid Hypofunction against Iodine and Copper Deficiency

Natalia M. Voronych-Semchenko
Ivano-Frankivsk National Medical University, Ministry of Health of Ukraine, Ivano-Frankivsk, Ukraine
Tetyana V. Guranych
Ivano-Frankivsk National Medical University, Ministry of Health of Ukraine, Ivano-Frankivsk, Ukraine

RÉSUMÉ

Thyroid status, copper balance, correlation of processes of peroxide oxidation of lipids (POL), proteins (POP), antioxidant defense (AOD) were examined in experiments on rats with hypofunction of thyroid gland against iodine monodeficit (THI) and combined iodine and copper deficiency (THI+Cu). It has been found that combined deficiency of microelements is accompanied by copper redistribution between different tissues (an increase in the levels of the latter in the red blood cell mass and the brain, and a decrease in copper content in the myocardium), as well as essential changes in indexes of hypothalamic-pituitary-thyroid axis, oxygen-dependent metabolism, anti-radical protection, exacerbating negative effects of each of them on the body. It has been revealed that THI+Cu inhibits oxygen-dependent processes, as evidenced by a decrease in the content of dyenic conjugates (DC) by 69.70% in the thyroid gland, TBA-reacting products (TBA-RP) by 47.72% in the diencephalon, the products of oxidative modified proteins (OMP) by 37.10 − 98.98% in the tissues of the diencephalon, the thyroid gland and the liver against the background of selective activation of peroxidation in the blood serum (an increase in TBA-RP content 7.11 times), and in the myocardium (an increase in DC level 2.86 times, OMP − 2.64 times) in comparison with the same indexes in intact animals. The results obtained (manifestations of the POL and POP processes, a decrease in copper concentration in the myocardium of examined animals) let us suppose the key role of microelement disbalance and metabolic mechanisms in pathogenesis of cardiac pathology against the background of thyroid dysfunction. The development of HTGI+Cu exhausts the resources of AOD, as evidenced by a decrease in the activity of catalase (by 47.05%), superoxide dismutase (by 33.13%), and saturation of transferrin with iron (by 56.76%) in comparison with the control data. The long-term disturbances of AOD may be the reason for enhancing oxygen-dependent processes and the development of pathological changes in separate physiological systems of the body.