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International Journal of Physiology and Pathophysiology
Effects of Deltaran and Melatonin on Immune System in Rats in Experimental Contact Dermatitis
Oleksii O. Shandra
"Odessa National Medical University"
We investigated the activity of humoral and cellular links of immunity and leukocyte functional stability indicators in rats with experimental contact dermatitis (ECD) under pharmacological correction by application of deltaran and melatonin. Chronic experiments were performed on the model of chrome-induced ECD. Complex pharmacological correction of humoral and cellular links of immunity and leukocyte stability was assessed using separate and combined administrations of deltaran and melatonin. The results have shown the pronounced disturbances in humoral and cellular links of immunity, as well as neutrophil and lymphocyte functional stability under chrome-induced ECD in rats. Violations of the functional activity of the immune system were corrected by applications of deltaran and melatonin. The activity of the therapeutic complex had exponential character.
MOTS CLÉS: experimental contact dermatitis, immune reactivity, neutrophil alteration index, lymphocyte alteration index, deltaran, melatonin, pharmacological correction
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