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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v9.i4.10
pages 287-293

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro

O. A. Znachkova
O.O. Bogomolets National Medical University, Kyiv
Irina V. Lushnikova
O.O. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
Galina G. Skibo
A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
M. Y. Antonenko
O.O. Bogomolets National Medical University, Kyiv
Nana V. Voitenko
O.O. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

RÉSUMÉ

The direct influence of materials for the root canal sealing in vitro on cultured nerve tissue sections, in particular the hippocampus slices, was investigated. According to the results of the study, the materials with the minimum toxic effect include resin pins, endopharmaceuticals AH-Plus, and acroseal, and the group with pronounced neurotoxic effects includes materials RealSeal and foredent. By the degree of toxicity, the test materials can be distributed as follows: resin pins < AH-Plus < acroseal < RealSeal < foredent. The results obtained can be used as recommendations to dentists regarding the choice of endohermetics, taking into account their neurotoxic properties in order to prevent unwanted complications.


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