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International Journal of Physiology and Pathophysiology
SJR: 0.116

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v2.i1.80
pages 79-85

Signal Function of Potassium Channels - Clinical Aspects

Igor S. Magura
Bogomoletz Institute of Physiology of National Academy of Science of Ukraine, Kyiv
Olena I. Magura
Bogomoletz Institute of Physiology of National Academy of Science of Ukraine, Kyiv
Olga V. Dolga
Bogomoletz Institute of Physiology of National Academy of Science of Ukraine, Kyiv
Nelly Kh. Pogorela
Bogomoletz Institute of Physiology of National Academy of Science of Ukraine, Kyiv
N. A. Bogdanova
Bogomoletz Institute of Physiology of National Academy of Science of Ukraine, Kyiv
Sh. Ageev
Bogomoletz Institute of Physiology of National Academy of Science of Ukraine, Kyiv

RÉSUMÉ

Potassium (K+) channels are the most diverse class of ion channels, and are important for regulating neuronal excitability and signaling activity in a variety of ways. They are major determinants of membrane excitability, influencing the resting potential of membranes, wave forms and frequencies of action potentials, and thresholds of excitation. Voltage- gated K+ cannels exist not as independent units merely responding to changes in transmembrane potential but as macromolecular complexes able to integrate a plethora of cellular signals that fine tune channel activities. There are a wide variety of therapeutic agents that are targeted to non-K+ channels, but result in unintended block of K+ channels. This K+ channel block can result in potentially serious and sometimes even fatal side effects.


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