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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v8.i2.70
pages 165-175

Effects of Hypoxic Preconditioning on the Mechanisms of Oxygen Transport and Oxidative Damage during Hepatic Ischemia-Reperfusion Syndrome in Rabbits

Michail N. Khodosovsky
Grodno State Medical University, Grodno, Belarus

RÉSUMÉ

The effects of hypoxic preconditioning (HP) on the blood oxygen-binding properties and liver oxidative damages were determined during hepatic ischemia-reperfusion (HIR) syndrome in rabbits. Animals were randomized into two experimental groups: 1st (HIR) – hepatic ischemia (30 min by Pringle maneuver) and reperfusion (120 min); 2nd (HP+HIR) – HP session prior to hepatic ischemia-reperfusion (rabbits were passed through hypoxic chamber at 3500 m altitude during 1 hr/day, 3 times a day after day). The parameters of the function of blood oxygen transport (p50, pCO2, pO2, pH, HCO3-, actual excess of bases, etc), lipid peroxidation products (diene conjugates, Schiff bases), and activities of hepatic markers, namely alanine aminotransferase and aspartate aminotransferase (ALT, AST) were detected. It has been revealed that HIR leads to a decline in hemoglobin oxygen affinity, an activation of lipid peroxidation processes, and the elevation of ALT and AST activities in the first group. Hypoxic preconditioning (2nd group) markedly increased hemoglobin oxygen affinity, reduced the lipid peroxidation processes and ALT and AST activities in the blood during HIR. Thus, HP has a protective effect on the liver in HIR through the elevation of hemoglobin oxygen affinity, which reduces hepatic oxidative damage.


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