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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v4.i1.30
pages 17-26

Cardiohemodynamics and Efficiency of the Frank-Starling Mechanism in Spontaneously Hypertensive Rats

Nataliya A. Dorofeyeva
Bogomolets Institute of Physiology of National Academy of Sciences of Ukraine, Kyiv, Ukraine
Mariya O. Kuzmenko
Bogomolets Institute of Physiology of National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tetyana V Shimanskaya
Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kyiv
Vadim F. Sagach
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

RÉSUMÉ

In a study on rats with genetically determined hypertension and control Wistar rats, we investigated the features of cardio-hemodynamics and an efficiency of Frank-Starling mechanism. Rats were anesthetized with urethane (1.25 g / kg, i.p). Changes in the left ventricular pressure and volume with visualization of the pressure-volume curves during the cardiac cycle were recorded using ultra small catheter 2F ("Millar Instruments", USA). Cardio-hemodynamic parameters of the left ventricle were analyzed using PVAN 3.6 program. It has been found that spontaneously hypertensive rats, at rest, demonstrate less efficient heart function at higher energy and oxygen consumption. After volume loading, an increase in the performance of the heart pump and contractile functions is less pronounced, compared to those in rats of the control group. Frank-Starling mechanism has been shown to be inhibited, when arterial stiffness increases. Thus, less efficient heart performance in rats with genetically determined hypertension to loading may be associated with reduced functional reserves of the heart and increased arterial stiffness.


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