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International Journal of Physiology and Pathophysiology
SJR: 0.106

ISSN Imprimer: 2155-014X
ISSN En ligne: 2155-0158

Archives: Volume 1, 2010 to Volume 9, 2018

International Journal of Physiology and Pathophysiology

DOI: 10.1615/IntJPhysPathophys.v4.i1.10
pages 1-9

Normobaric Hyperoxia Affects Osteogenesis in Rats

Irina G. Litovka
Bogomolets Institute of Physiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
Vadim A. Berezovskiy
Bogomolets Institute of Physiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
Tatiana M. Zamorska
Bogomolets Institute of Physiology National Academy of Sciences of Ukraine, Kyiv, Ukraine

RÉSUMÉ

We studied the effects of normobaric hyperoxia on bone metabolism in 3- and 12-month-old male Wistar rats. An exposure of the young rats (3 months) to the 14-hour daily sessions of normobaric hyperoxia (90% O2) is accompanied by a significant decrease in the concentration of C-terminal propeptides of the collagen type I and acid phosphatase activity by 36% and 32%, correspondingly, whereas an activity of alkaline phosphatase increases by 64%, and concentration of pyridinoline, β-CrossLaps and glycosaminoglycans by 37%, 8%, and 72%, respectively, in the blood serum. We believe that 14-day long normobaric hyperoxia (90%) impairs collagen synthesis. In adult rats under the same conditions, the concentration of glycosaminoglycans significantly increases (by 60%) relative to the control values. After 28 sessions of breathing with normobaric gas mixture containing 90% O2, this parameter increases by 195%. Acid phosphatase activity and the tartrat-resistant acid phosphatase activity decrease by 18 − 25% after breathing with normobaric gas mixture containing 40% and 90% O2 for 14 and 28 days. We suggest that in adult animals, 90% hyperoxia does not affect the activity of osteoblasts, but it breaks the link between glycosaminoglycans and collagen fibrils, decreases lysosomal enzyme activities, produced by osteoclasts, which can inhibit osteogenesis.


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